tetano
Editor, Senior Moderator
Epidemiol Infect. 2015 Sep 18:1-10. [Epub ahead of print]
[h=1]Predictors of hospitalization for lower respiratory tract infection in children aged <2 years in the province of Quebec, Canada.[/h] Zhou Z[SUP]1[/SUP], Gilca R[SUP]2[/SUP], Deceuninck G[SUP]1[/SUP], Boucher FD[SUP]3[/SUP], Charest H[SUP]4[/SUP], DE Wals P[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Young age, adverse environmental conditions and infectious agents are established risk factors of lower respiratory tract infection (LRTI), whereas pneumococcal conjugate vaccines may be protective. To explore their relative role as predictors of hospitalizations under the continental climate prevailing in the province of Quebec, Canada, an ecological study was performed. Records with a main diagnosis of LRTI in children born during 2007-2010 and observed up to their second-year anniversary were extracted from the provincial hospital administrative database. Respiratory virus surveillance data and statistics on ambient air temperature were obtained. Vaccine use in different birth cohorts was derived from the Quebec City Immunization Registry. Additive and multiplicative Poisson regression models were applied to estimate attributable fractions. Age, month of birth, ambient temperature, and respiratory syncytial virus (RSV), human metapneumovirus (hMPV) and influenza-positive test proportions were significant predictors of LRTI hospitalizations. No substantial differences were observed in cohorts exposed to the 7-valent or 10-valent pneumococcal conjugate vaccines. In the additive model, the fraction of hospitalizations explained by temperature variation was 37%, whereas RSV circulation explained 28%, hMPV 4% and influenza 1%. Complex interplay between biological, environmental and social mechanisms may explain the important role of ambient air temperature in predicting LRTI hospitalization risk in young children.
[h=4]KEYWORDS:[/h] Ambient temperature; ecological study; hospital admissions; pneumococcal conjugate vaccine; respiratory infections; respiratory virus
PMID: 26381086 [PubMed - as supplied by publisher]
[h=1]Predictors of hospitalization for lower respiratory tract infection in children aged <2 years in the province of Quebec, Canada.[/h] Zhou Z[SUP]1[/SUP], Gilca R[SUP]2[/SUP], Deceuninck G[SUP]1[/SUP], Boucher FD[SUP]3[/SUP], Charest H[SUP]4[/SUP], DE Wals P[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Young age, adverse environmental conditions and infectious agents are established risk factors of lower respiratory tract infection (LRTI), whereas pneumococcal conjugate vaccines may be protective. To explore their relative role as predictors of hospitalizations under the continental climate prevailing in the province of Quebec, Canada, an ecological study was performed. Records with a main diagnosis of LRTI in children born during 2007-2010 and observed up to their second-year anniversary were extracted from the provincial hospital administrative database. Respiratory virus surveillance data and statistics on ambient air temperature were obtained. Vaccine use in different birth cohorts was derived from the Quebec City Immunization Registry. Additive and multiplicative Poisson regression models were applied to estimate attributable fractions. Age, month of birth, ambient temperature, and respiratory syncytial virus (RSV), human metapneumovirus (hMPV) and influenza-positive test proportions were significant predictors of LRTI hospitalizations. No substantial differences were observed in cohorts exposed to the 7-valent or 10-valent pneumococcal conjugate vaccines. In the additive model, the fraction of hospitalizations explained by temperature variation was 37%, whereas RSV circulation explained 28%, hMPV 4% and influenza 1%. Complex interplay between biological, environmental and social mechanisms may explain the important role of ambient air temperature in predicting LRTI hospitalization risk in young children.
[h=4]KEYWORDS:[/h] Ambient temperature; ecological study; hospital admissions; pneumococcal conjugate vaccine; respiratory infections; respiratory virus
PMID: 26381086 [PubMed - as supplied by publisher]