tetano
Editor, Senior Moderator
J Infect Dis. 2017 Jun 16. doi: 10.1093/infdis/jix281. [Epub ahead of print]
[h=1]Proinflammatory Cytokine Responses in Extra-Respiratory Tissues During Severe Influenza.[/h] Short KR[SUP]1,[/SUP][SUP]2[/SUP], Veeris R[SUP]1[/SUP], Leijten LM[SUP]1[/SUP], van den Brand JM[SUP]1[/SUP], Jong VL[SUP]1,[/SUP][SUP]3[/SUP], Stittelaar K[SUP]4[/SUP], Osterhaus ADME[SUP]1,[/SUP][SUP]5[/SUP], Andeweg A[SUP]1[/SUP], van Riel D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Severe influenza is often associated with disease manifestations outside the respiratory tract. While proinflammatory cytokines can be detected in the lungs and blood of infected patients, the role of extra-respiratory organs in the production of proinflammatory cytokines is unknown. Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor α, interleukin-6, and interleukin-8 in the respiratory tract and central nervous system. In addition, H5N1 virus induced cytokines in the heart, pancreas, spleen, liver, and jejunum. Together, these data suggest that extra-respiratory tissues contribute to systemic cytokine responses, which may increase the severity of influenza.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] H1N1; H5N1; cytokine storm; cytokines; extra-respiratory responses; influenza; pathogenesis; systemic disease
PMID: 28973159 DOI: 10.1093/infdis/jix281
[h=1]Proinflammatory Cytokine Responses in Extra-Respiratory Tissues During Severe Influenza.[/h] Short KR[SUP]1,[/SUP][SUP]2[/SUP], Veeris R[SUP]1[/SUP], Leijten LM[SUP]1[/SUP], van den Brand JM[SUP]1[/SUP], Jong VL[SUP]1,[/SUP][SUP]3[/SUP], Stittelaar K[SUP]4[/SUP], Osterhaus ADME[SUP]1,[/SUP][SUP]5[/SUP], Andeweg A[SUP]1[/SUP], van Riel D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Severe influenza is often associated with disease manifestations outside the respiratory tract. While proinflammatory cytokines can be detected in the lungs and blood of infected patients, the role of extra-respiratory organs in the production of proinflammatory cytokines is unknown. Here, we show that both 2009 pandemic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce expression of tumor necrosis factor α, interleukin-6, and interleukin-8 in the respiratory tract and central nervous system. In addition, H5N1 virus induced cytokines in the heart, pancreas, spleen, liver, and jejunum. Together, these data suggest that extra-respiratory tissues contribute to systemic cytokine responses, which may increase the severity of influenza.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] H1N1; H5N1; cytokine storm; cytokines; extra-respiratory responses; influenza; pathogenesis; systemic disease
PMID: 28973159 DOI: 10.1093/infdis/jix281