tetano
Editor, Senior Moderator
Psychiatr Pol
. 2025 Dec 31;58(6):957-980.
doi: 10.12740/PP/190406. Epub 2025 Dec 31. Emotional and sleep disturbances among patients previously hospitalized due to COVID-19
[Article in English, Polish]
Żaneta Chatys-Bogacka[SUP] 1 2 [/SUP], Iwona Mazurkiewicz[SUP] 1 2 [/SUP], Joanna Słowik[SUP] 3 [/SUP], Agnieszka Słowik[SUP] 1 2 [/SUP], Leszek Drabik[SUP] 4 5 [/SUP], Marcin Wnuk[SUP] 1 2 [/SUP]
Affiliations
Objectives: To evaluate incidence of emotional and sleep disturbances (ESDs) in patients after hospitalization due to COVID-19, identify long-term predictors, and understand their influence on brain fog and quality of life at work (QWL).
Methods: Patients of 18 or more years retrospectively reported ESDs (sadness, anxiety, restlessness, insomnia, excessive daytime sleepiness, nightmares), brain fog symptoms (BFS), QWL before COVID-19 and within 0-4, 4-12, and >12 weeks postinfection using paper or online validated questionnaire. Data regarding age, sex, comorbidities, pre-admission therapy, and laboratory results were collected. Finally, the study included 181 hospitalized individuals (mean age 56.02 ± 13.02 years; 37.02% women).
Results: COVID-19 increased 1.6-fold to 2.2-fold incidence of ESDs within 0-4, 4-12, and >12 weeks post-infection (66.85%, 60.77%, and 50.28%, respectively). In the multivariable model, new-onset ESDs after COVID-19 were predicted by hemoglobin levels in the acute phase of infection (OR = 0.64; 95% CI: 0.50-0.80 per g/L; p = 0.001). In patients with pre-existing and new-onset ESDs, COVID-19 showed a 1.9-fold and 3.9-fold increase in BFS within >12 weeks post-infection, respectively. Deterioration in QWL >12 weeks post-COVID was associated with age (OR = 0.62; 95% CI: 0.37-0.73 per 10 years; p < 0.001), female sex (OR = 3.47; 95% CI: 1.40-8.56; p = 0.007), pre-existing (OR = 21.58; 95% CI: 2.57-181.30; p = 0.005) and new-onset ESDs (OR = 30.88; 95% CI: 3.85-247.90; p = 0.001).
Conclusions: During follow-up, most patients with COVID-19 suffer from ESDs that are predicted by hemoglobin levels. The ESDs increase the risk of concomitant BFS. The ESDs, particularly sadness, restlessness, insomnia, and excessive daytime sleepiness, strongly affect QWL >12 weeks after COVID-19.
Keywords: COVID-19; brain fog; emotional and sleep disturbances.
. 2025 Dec 31;58(6):957-980.
doi: 10.12740/PP/190406. Epub 2025 Dec 31. Emotional and sleep disturbances among patients previously hospitalized due to COVID-19
[Article in English, Polish]
Żaneta Chatys-Bogacka[SUP] 1 2 [/SUP], Iwona Mazurkiewicz[SUP] 1 2 [/SUP], Joanna Słowik[SUP] 3 [/SUP], Agnieszka Słowik[SUP] 1 2 [/SUP], Leszek Drabik[SUP] 4 5 [/SUP], Marcin Wnuk[SUP] 1 2 [/SUP]
Affiliations
- PMID: 40178556
- DOI: 10.12740/PP/190406
Objectives: To evaluate incidence of emotional and sleep disturbances (ESDs) in patients after hospitalization due to COVID-19, identify long-term predictors, and understand their influence on brain fog and quality of life at work (QWL).
Methods: Patients of 18 or more years retrospectively reported ESDs (sadness, anxiety, restlessness, insomnia, excessive daytime sleepiness, nightmares), brain fog symptoms (BFS), QWL before COVID-19 and within 0-4, 4-12, and >12 weeks postinfection using paper or online validated questionnaire. Data regarding age, sex, comorbidities, pre-admission therapy, and laboratory results were collected. Finally, the study included 181 hospitalized individuals (mean age 56.02 ± 13.02 years; 37.02% women).
Results: COVID-19 increased 1.6-fold to 2.2-fold incidence of ESDs within 0-4, 4-12, and >12 weeks post-infection (66.85%, 60.77%, and 50.28%, respectively). In the multivariable model, new-onset ESDs after COVID-19 were predicted by hemoglobin levels in the acute phase of infection (OR = 0.64; 95% CI: 0.50-0.80 per g/L; p = 0.001). In patients with pre-existing and new-onset ESDs, COVID-19 showed a 1.9-fold and 3.9-fold increase in BFS within >12 weeks post-infection, respectively. Deterioration in QWL >12 weeks post-COVID was associated with age (OR = 0.62; 95% CI: 0.37-0.73 per 10 years; p < 0.001), female sex (OR = 3.47; 95% CI: 1.40-8.56; p = 0.007), pre-existing (OR = 21.58; 95% CI: 2.57-181.30; p = 0.005) and new-onset ESDs (OR = 30.88; 95% CI: 3.85-247.90; p = 0.001).
Conclusions: During follow-up, most patients with COVID-19 suffer from ESDs that are predicted by hemoglobin levels. The ESDs increase the risk of concomitant BFS. The ESDs, particularly sadness, restlessness, insomnia, and excessive daytime sleepiness, strongly affect QWL >12 weeks after COVID-19.
Keywords: COVID-19; brain fog; emotional and sleep disturbances.