tetano
Editor, Senior Moderator
Reprod Toxicol
. 2020 Jun 10;S0890-6238(20)30165-9.
doi: 10.1016/j.reprotox.2020.06.006. Online ahead of print.
The Absence of Coronavirus in Expressed Prostatic Secretion in COVID-19 Patients in Wuhan City
Shiqi Zhang[SUP] 1 [/SUP], Xiaobo Wang[SUP] 2 [/SUP], Hong Zhang[SUP] 2 [/SUP], Aihui Xu[SUP] 3 [/SUP], Guanghe Fei[SUP] 3 [/SUP], Xiao Jiang[SUP] 4 [/SUP], Jun Tu[SUP] 5 [/SUP], Guangbo Qu[SUP] 6 [/SUP], Xihai Xu[SUP] 7 [/SUP], Yonghuai Li[SUP] 8 [/SUP]
Affiliations
Abstract
Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and possibly exclude the sexual transmission of COVID-19.
Keywords: COVID-19; SARS-CoV-2; expressed prostatic secretion; prostate.
. 2020 Jun 10;S0890-6238(20)30165-9.
doi: 10.1016/j.reprotox.2020.06.006. Online ahead of print.
The Absence of Coronavirus in Expressed Prostatic Secretion in COVID-19 Patients in Wuhan City
Shiqi Zhang[SUP] 1 [/SUP], Xiaobo Wang[SUP] 2 [/SUP], Hong Zhang[SUP] 2 [/SUP], Aihui Xu[SUP] 3 [/SUP], Guanghe Fei[SUP] 3 [/SUP], Xiao Jiang[SUP] 4 [/SUP], Jun Tu[SUP] 5 [/SUP], Guangbo Qu[SUP] 6 [/SUP], Xihai Xu[SUP] 7 [/SUP], Yonghuai Li[SUP] 8 [/SUP]
Affiliations
- PMID: 32534021
- DOI: 10.1016/j.reprotox.2020.06.006
Abstract
Due to the cellular entry of the novel coronavirus (SARS-CoV-2) modulated by angiotensin converting enzyme 2 (ACE2), the ACE2 bearing prostate is therefore hypothesized as a susceptible organ to COVID-19. To delineate whether the pathogenic SARS-CoV-2 of the coronavirus disease (COVID-19) could be detected in the expressed prostatic secretion (EPS), a total of ten male patients with confirmed COVID-19 were recruited. All patients were stratified into two groups: one group with positive nasopharyngeal swabbing SARS-CoV-2 within 3 days of the EPS taken day (PNS group, n = 3) and the other group with previously positive nasopharyngeal swabbing SARS-CoV-2 but turned negative before the taken day (PNNS group, n = 7). The COVID-19 patients showed elevated inflammatory indictors, i.e. C-reaction protein (3.28 (1.14, 33.33) mg/L), erythrocyte sedimentation rate (22.50 (8.00, 78.50) mm/h), and interleukin-6 (6.49 (4.96, 21.09) pg/ml). Serum IgM against SARS-CoV-2 was only positive in the PNS group, whereas serum IgG was positive for all patients. Furthermore, our data showed for the first time that none of the COVID-19 patients had positive SARS-CoV-2 RNA in EPS. To this end, this study found the negativity of SARS-CoV-2 in EPS and possibly exclude the sexual transmission of COVID-19.
Keywords: COVID-19; SARS-CoV-2; expressed prostatic secretion; prostate.