tetano
Editor, Senior Moderator
Res Pract Thromb Haemost
. 2020 Jun 21;4(5):737-740.
doi: 10.1002/rth2.12397. eCollection 2020 Jul.
Potential role of platelets in COVID-19: Implications for thrombosis
Milka Koupenova[SUP] 1 [/SUP]
Affiliations
Abstract
For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
Keywords: COVID‐19; SARS‐CoV‐2; immunity; platelets; thrombosis.
. 2020 Jun 21;4(5):737-740.
doi: 10.1002/rth2.12397. eCollection 2020 Jul.
Potential role of platelets in COVID-19: Implications for thrombosis
Milka Koupenova[SUP] 1 [/SUP]
Affiliations
- PMID: 32685881
- PMCID: PMC7283793
- DOI: 10.1002/rth2.12397
Abstract
For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
Keywords: COVID‐19; SARS‐CoV‐2; immunity; platelets; thrombosis.