tetano
Editor, Senior Moderator
Res Pract Thromb Haemost
. 2020 Jul 11;4(5):744-751.
doi: 10.1002/rth2.12400. eCollection 2020 Jul.
Thrombosis and coagulopathy in COVID-19: An illustrated review
Marcel Levi[SUP] 1 [/SUP], Beverley J Hunt[SUP] 2 [/SUP]
Affiliations
Abstract
This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID-19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute-phase proteins, very high levels of D-dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID-19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).
Keywords: COVID‐19; coagulation; coagulopathy; novel coronavirus; thrombosis.
. 2020 Jul 11;4(5):744-751.
doi: 10.1002/rth2.12400. eCollection 2020 Jul.
Thrombosis and coagulopathy in COVID-19: An illustrated review
Marcel Levi[SUP] 1 [/SUP], Beverley J Hunt[SUP] 2 [/SUP]
Affiliations
- PMID: 32685883
- PMCID: PMC7354416
- DOI: 10.1002/rth2.12400
Abstract
This illustrated review discusses the haemostatic changes seen in patients with severe coronavirus disease 2019 (COVID-19) infection and their possible causes. We discuss the crosstalk between inflammation and coagulation resulting in high levels of acute-phase proteins, very high levels of D-dimers, and absence of disseminated intravascular coagulation seen in patients with severe COVID-19. There appear to be high rates of venous thromboembolism and also, what has been poorly described before in acute lung injury, a high rate of pulmonary immunothrombosis (thrombosis secondary to inflammation).
Keywords: COVID‐19; coagulation; coagulopathy; novel coronavirus; thrombosis.