tetano
Editor, Senior Moderator
Respirol Case Rep
. 2022 Mar 16;10(4):e0934.
doi: 10.1002/rcr2.934. eCollection 2022 Apr.
Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID-19-infected autopsy case
Akiko Tamura[SUP] 1 [/SUP], Ryosuke Imai[SUP] 1 [/SUP], Yutaka Tomishima[SUP] 1 [/SUP], Naoki Nishimura[SUP] 1 [/SUP]
Affiliations
Abstract
We encountered a patient with severe coronavirus disease 2019 (COVID-19)-related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over-activated immune responses against COVID-19 infection. When COVID-19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset.
Keywords: COVID‐19; autopsy; diffuse alveolar damage; pulmonary fibrosis.
. 2022 Mar 16;10(4):e0934.
doi: 10.1002/rcr2.934. eCollection 2022 Apr.
Progressive pulmonary fibrosis due to diffuse alveolar damage in a COVID-19-infected autopsy case
Akiko Tamura[SUP] 1 [/SUP], Ryosuke Imai[SUP] 1 [/SUP], Yutaka Tomishima[SUP] 1 [/SUP], Naoki Nishimura[SUP] 1 [/SUP]
Affiliations
- PMID: 35342636
- PMCID: PMC8926900
- DOI: 10.1002/rcr2.934
Abstract
We encountered a patient with severe coronavirus disease 2019 (COVID-19)-related pneumonia, who died of progressive respiratory acidosis after 2 months of treatment with mechanical ventilation. The autopsy revealed diffuse alveolar damage (DAD) without any active signs of fungal or bacterial infections, suggesting prolonged and over-activated immune responses against COVID-19 infection. When COVID-19 patients develop acute respiratory distress syndrome, it is essential to remember that the infection can progress to DAD a few months after the disease onset.
Keywords: COVID‐19; autopsy; diffuse alveolar damage; pulmonary fibrosis.
