tetano
Editor, Senior Moderator
Rev Med Virol
. 2020 Jun 5;e2112.
doi: 10.1002/rmv.2112. Online ahead of print.
Comparison of Confirmed COVID-19 With SARS and MERS Cases - Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes: A Systematic Review and Meta-Analysis
Ali Pormohammad[SUP] 1 [/SUP], Saied Ghorbani[SUP] 2 [/SUP], Alireza Khatami[SUP] 2 [/SUP], Rana Farzi[SUP] 3 [/SUP], Behzad Baradaran[SUP] 4 5 [/SUP], Diana L Turner[SUP] 6 [/SUP], Raymond J Turner[SUP] 7 [/SUP], Nathan C Bahr[SUP] 8 [/SUP], Juan-Pablo Idrovo[SUP] 9 [/SUP]
Affiliations
Abstract
Introduction: Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features.
Method: We searched all relevant literature published up to February 28, 2020. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Study has been registered in the PROSPERO database (ID 176106).
Result: Overall 114 articles included in this study; 52 251 COVID-19 confirmed patients (20 studies), 10 037 SARS (51 studies), and 8139 MERS patients (43 studies) were included. The most common symptom was fever; COVID-19 (85.6%, P < .001), SARS (96%, P < .001), and MERS (74%, P < .001), respectively. Analysis showed that 84% of Covid-19 patients, 86% of SARS patients, and 74.7% of MERS patients had an abnormal chest X-ray. The mortality rate in COVID-19 (5.6%, P < .001) was lower than SARS (13%, P < .001) and MERS (35%, P < .001) between all confirmed patients.
Conclusions: At the time of submission, the mortality rate in COVID-19 confirmed cases is lower than in SARS- and MERS-infected patients. Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data.
Keywords: COVID-19; Middle East respiratory syndrome coronavirus; SARS virus; coronavirus; meta-analysis; severe acute respiratory syndrome.
. 2020 Jun 5;e2112.
doi: 10.1002/rmv.2112. Online ahead of print.
Comparison of Confirmed COVID-19 With SARS and MERS Cases - Clinical Characteristics, Laboratory Findings, Radiographic Signs and Outcomes: A Systematic Review and Meta-Analysis
Ali Pormohammad[SUP] 1 [/SUP], Saied Ghorbani[SUP] 2 [/SUP], Alireza Khatami[SUP] 2 [/SUP], Rana Farzi[SUP] 3 [/SUP], Behzad Baradaran[SUP] 4 5 [/SUP], Diana L Turner[SUP] 6 [/SUP], Raymond J Turner[SUP] 7 [/SUP], Nathan C Bahr[SUP] 8 [/SUP], Juan-Pablo Idrovo[SUP] 9 [/SUP]
Affiliations
- PMID: 32502331
- DOI: 10.1002/rmv.2112
Abstract
Introduction: Within this large-scale study, we compared clinical symptoms, laboratory findings, radiographic signs, and outcomes of COVID-19, SARS, and MERS to find unique features.
Method: We searched all relevant literature published up to February 28, 2020. Depending on the heterogeneity test, we used either random or fixed-effect models to analyze the appropriateness of the pooled results. Study has been registered in the PROSPERO database (ID 176106).
Result: Overall 114 articles included in this study; 52 251 COVID-19 confirmed patients (20 studies), 10 037 SARS (51 studies), and 8139 MERS patients (43 studies) were included. The most common symptom was fever; COVID-19 (85.6%, P < .001), SARS (96%, P < .001), and MERS (74%, P < .001), respectively. Analysis showed that 84% of Covid-19 patients, 86% of SARS patients, and 74.7% of MERS patients had an abnormal chest X-ray. The mortality rate in COVID-19 (5.6%, P < .001) was lower than SARS (13%, P < .001) and MERS (35%, P < .001) between all confirmed patients.
Conclusions: At the time of submission, the mortality rate in COVID-19 confirmed cases is lower than in SARS- and MERS-infected patients. Clinical outcomes and findings would be biased by reporting only confirmed cases, and this should be considered when interpreting the data.
Keywords: COVID-19; Middle East respiratory syndrome coronavirus; SARS virus; coronavirus; meta-analysis; severe acute respiratory syndrome.