tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2015 Jul 9. [Epub ahead of print]
[h=1]Role of Nasopharyngeal Bacteria and Respiratory Viruses in Acute Symptoms of Young Children.[/h] Uitti JM[SUP]1[/SUP], T?htinen PA, Laine MK, Huovinen P, Ruuskanen O, Ruohola A.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The spectrum of acute symptoms in young outpatient children with respiratory tract infection (RTI) is variable and it cannot be explained by the diagnosis of acute otitis media (AOM) vs. uncomplicated RTI. We studied if the variation of symptoms is explained by the nasopharyngeal bacteria and/or respiratory viruses.
[h=4]METHODS:[/h] Children aged 6-35 months with acute symptoms with (n=201) or without (n=225) AOM were eligible in this cross-sectional study. We analyzed their nasopharyngeal samples for pathogenic bacteria by culture and for respiratory viruses by PCR. We surveyed 17 symptoms (fever, respiratory, ear-related, non-specific, gastrointestinal) with a structured questionnaire.
[h=4]RESULTS:[/h] Fever had a positive association with influenza viruses (odds ratio (OR), 6.61; 95% confidence interval (CI), 1.66-26.27), human metapneumovirus (OR, 3.84; 95% CI, 1.25-11.77), coronaviruses (OR, 3.45; 95% CI, 1.53-7.75) and parainfluenza viruses (OR, 2.18; 95% CI, 1.07-4.47). Rhinitis (OR, 5.07; 95% CI, 1.93-13.36), nasal congestion (OR, 2.03; 95% CI, 1.25-3.31) and cough (OR, 1.91; 95% CI, 1.15-3.17) had positive associations with Moraxella catarrhalis. Furthermore, cough had a positive association with respiratory syncytial virus (OR, 7.20; 95% CI, 1.59-32.71) and parainfluenza viruses (OR, 2.79; 95% CI, 1.02-7.69).
[h=4]CONCLUSIONS:[/h] The variation of acute symptoms in young children may be influenced by both nasopharyngeal bacteria and respiratory viruses. Our results showed a strong association between fever and respiratory viruses; rhinitis, nasal congestion and cough were associated with M. catarrhalis, in the presence of viruses. Further studies are required to determine the possible synergistic role of M. catarrhalis in symptoms of RTI.
PMID: 26164848 [PubMed - as supplied by publisher]
[h=1]Role of Nasopharyngeal Bacteria and Respiratory Viruses in Acute Symptoms of Young Children.[/h] Uitti JM[SUP]1[/SUP], T?htinen PA, Laine MK, Huovinen P, Ruuskanen O, Ruohola A.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The spectrum of acute symptoms in young outpatient children with respiratory tract infection (RTI) is variable and it cannot be explained by the diagnosis of acute otitis media (AOM) vs. uncomplicated RTI. We studied if the variation of symptoms is explained by the nasopharyngeal bacteria and/or respiratory viruses.
[h=4]METHODS:[/h] Children aged 6-35 months with acute symptoms with (n=201) or without (n=225) AOM were eligible in this cross-sectional study. We analyzed their nasopharyngeal samples for pathogenic bacteria by culture and for respiratory viruses by PCR. We surveyed 17 symptoms (fever, respiratory, ear-related, non-specific, gastrointestinal) with a structured questionnaire.
[h=4]RESULTS:[/h] Fever had a positive association with influenza viruses (odds ratio (OR), 6.61; 95% confidence interval (CI), 1.66-26.27), human metapneumovirus (OR, 3.84; 95% CI, 1.25-11.77), coronaviruses (OR, 3.45; 95% CI, 1.53-7.75) and parainfluenza viruses (OR, 2.18; 95% CI, 1.07-4.47). Rhinitis (OR, 5.07; 95% CI, 1.93-13.36), nasal congestion (OR, 2.03; 95% CI, 1.25-3.31) and cough (OR, 1.91; 95% CI, 1.15-3.17) had positive associations with Moraxella catarrhalis. Furthermore, cough had a positive association with respiratory syncytial virus (OR, 7.20; 95% CI, 1.59-32.71) and parainfluenza viruses (OR, 2.79; 95% CI, 1.02-7.69).
[h=4]CONCLUSIONS:[/h] The variation of acute symptoms in young children may be influenced by both nasopharyngeal bacteria and respiratory viruses. Our results showed a strong association between fever and respiratory viruses; rhinitis, nasal congestion and cough were associated with M. catarrhalis, in the presence of viruses. Further studies are required to determine the possible synergistic role of M. catarrhalis in symptoms of RTI.
PMID: 26164848 [PubMed - as supplied by publisher]