tetano
Editor, Senior Moderator
J Asian Nat Prod Res. 2018 Nov 10:1-10. doi: 10.1080/10286020.2018.1520221. [Epub ahead of print]
[h=1]Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways.[/h] Zhong M[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Wang HQ[SUP]2[/SUP], Yan HY[SUP]2[/SUP], Wu S[SUP]2[/SUP], Gu ZY[SUP]3[/SUP], Li YH[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells. Thus, santin is a potential candidate for the future development of anti-IAV drugs. [Formula: see text].
[h=4]KEYWORDS:[/h] MAPKs; NF-κB; Santin; inflammatory cytokines; influenza A virus
PMID: 30417663 DOI: 10.1080/10286020.2018.1520221
[h=1]Santin inhibits influenza A virus replication through regulating MAPKs and NF-κB pathways.[/h] Zhong M[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Wang HQ[SUP]2[/SUP], Yan HY[SUP]2[/SUP], Wu S[SUP]2[/SUP], Gu ZY[SUP]3[/SUP], Li YH[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells. Thus, santin is a potential candidate for the future development of anti-IAV drugs. [Formula: see text].
[h=4]KEYWORDS:[/h] MAPKs; NF-κB; Santin; inflammatory cytokines; influenza A virus
PMID: 30417663 DOI: 10.1080/10286020.2018.1520221