tetano
Editor, Senior Moderator
Sci Rep
. 2023 Jul 24;13(1):11961.
doi: 10.1038/s41598-023-39157-8. Association between obesity and mortality in critically ill COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective observational study
Keiichiro Shimoyama[SUP] 1 [/SUP], Akira Endo[SUP] 2 3 [/SUP], Takashi Shimazui[SUP] 4 [/SUP], Takashi Tagami[SUP] 5 [/SUP], Kazuma Yamakawa[SUP] 6 [/SUP], Mineji Hayakawa[SUP] 7 [/SUP], Takayuki Ogura[SUP] 8 [/SUP], Atsushi Hirayama[SUP] 9 [/SUP], Hideo Yasunaga[SUP] 10 [/SUP], Jun Oda[SUP] 11 [/SUP]
Affiliations
This study aimed to determine whether obesity and disease outcomes are associated in patients with critically-ill coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation (IMV). This retrospective observational study using Japanese multicenter registry data included COVID-19 patients who required IMV and were discharged between January and September 2020. The patients were divided into the obese (body mass index [BMI] ≥ 25 kg/m[SUP]2[/SUP]) and nonobese (BMI < 25 kg/m[SUP]2[/SUP]) groups. Logistic regression models were used to analyze the association between obesity and disease outcomes. The primary outcome was in-hospital mortality; the secondary outcome was venovenous extracorporeal membrane oxygenation (VV-ECMO) implementation. Altogether, 477 patients were enrolled (obese, n = 235, median BMI, 28.2 kg/m[SUP]2[/SUP]; nonobese, n = 242, median BMI, 22.4 kg/m[SUP]2[/SUP]). Obesity was significantly associated with lower in-hospital mortality in the unadjusted logistic regression model (odds ratio 0.63; 95% confidence interval, 0.42-0.97; p = 0.033), but not with mortality in the adjusted logistic regression model using age, sex, and Charlson Comorbidity Index as covariates (p = 0.564). Obesity was not associated with VV-ECMO implementation in both unadjusted and adjusted models (unadjusted, p = 0.074; adjusted, p = 0.695). Obesity was not associated with outcomes in COVID-19 patients requiring IMV. Obesity may not be a risk factor for poor outcomes in these patients.
. 2023 Jul 24;13(1):11961.
doi: 10.1038/s41598-023-39157-8. Association between obesity and mortality in critically ill COVID-19 patients requiring invasive mechanical ventilation: a multicenter retrospective observational study
Keiichiro Shimoyama[SUP] 1 [/SUP], Akira Endo[SUP] 2 3 [/SUP], Takashi Shimazui[SUP] 4 [/SUP], Takashi Tagami[SUP] 5 [/SUP], Kazuma Yamakawa[SUP] 6 [/SUP], Mineji Hayakawa[SUP] 7 [/SUP], Takayuki Ogura[SUP] 8 [/SUP], Atsushi Hirayama[SUP] 9 [/SUP], Hideo Yasunaga[SUP] 10 [/SUP], Jun Oda[SUP] 11 [/SUP]
Affiliations
- PMID: 37488189
- DOI: 10.1038/s41598-023-39157-8
This study aimed to determine whether obesity and disease outcomes are associated in patients with critically-ill coronavirus disease 2019 (COVID-19) requiring invasive mechanical ventilation (IMV). This retrospective observational study using Japanese multicenter registry data included COVID-19 patients who required IMV and were discharged between January and September 2020. The patients were divided into the obese (body mass index [BMI] ≥ 25 kg/m[SUP]2[/SUP]) and nonobese (BMI < 25 kg/m[SUP]2[/SUP]) groups. Logistic regression models were used to analyze the association between obesity and disease outcomes. The primary outcome was in-hospital mortality; the secondary outcome was venovenous extracorporeal membrane oxygenation (VV-ECMO) implementation. Altogether, 477 patients were enrolled (obese, n = 235, median BMI, 28.2 kg/m[SUP]2[/SUP]; nonobese, n = 242, median BMI, 22.4 kg/m[SUP]2[/SUP]). Obesity was significantly associated with lower in-hospital mortality in the unadjusted logistic regression model (odds ratio 0.63; 95% confidence interval, 0.42-0.97; p = 0.033), but not with mortality in the adjusted logistic regression model using age, sex, and Charlson Comorbidity Index as covariates (p = 0.564). Obesity was not associated with VV-ECMO implementation in both unadjusted and adjusted models (unadjusted, p = 0.074; adjusted, p = 0.695). Obesity was not associated with outcomes in COVID-19 patients requiring IMV. Obesity may not be a risk factor for poor outcomes in these patients.