tetano
Editor, Senior Moderator
Sci Rep
. 2021 Dec 8;11(1):23644.
doi: 10.1038/s41598-021-02874-z.
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal
Ambroise D Ahouidi[SUP] #[/SUP][SUP] 1 [/SUP], Mary A Rodgers[SUP] #[/SUP][SUP] 2 [/SUP], Abdou Padane[SUP] 3 [/SUP], Nafissatou Leye[SUP] 3 [/SUP], Ana Olivo[SUP] 4 [/SUP], Moustapha Mbow[SUP] 3 [/SUP], Aminata Mboup[SUP] 3 [/SUP], Papa Alassane Diaw[SUP] 3 [/SUP], Aminata Dia[SUP] 3 [/SUP], Barbara Harris[SUP] 4 [/SUP], Yacine Amet Dia Padane[SUP] 3 [/SUP], Gora Lo[SUP] 3 [/SUP], Todd V Meyer[SUP] 4 [/SUP], Cyrille K Diedhiou[SUP] 3 [/SUP], Diabou Diagne[SUP] 3 [/SUP], Ndeye Coumba Toure Kane[SUP] 3 [/SUP], Gavin Cloherty[SUP] 4 [/SUP], Souleymane Mboup[SUP] 3 [/SUP]
Affiliations
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.
. 2021 Dec 8;11(1):23644.
doi: 10.1038/s41598-021-02874-z.
Emergence of novel combinations of SARS-CoV-2 spike receptor binding domain variants in Senegal
Ambroise D Ahouidi[SUP] #[/SUP][SUP] 1 [/SUP], Mary A Rodgers[SUP] #[/SUP][SUP] 2 [/SUP], Abdou Padane[SUP] 3 [/SUP], Nafissatou Leye[SUP] 3 [/SUP], Ana Olivo[SUP] 4 [/SUP], Moustapha Mbow[SUP] 3 [/SUP], Aminata Mboup[SUP] 3 [/SUP], Papa Alassane Diaw[SUP] 3 [/SUP], Aminata Dia[SUP] 3 [/SUP], Barbara Harris[SUP] 4 [/SUP], Yacine Amet Dia Padane[SUP] 3 [/SUP], Gora Lo[SUP] 3 [/SUP], Todd V Meyer[SUP] 4 [/SUP], Cyrille K Diedhiou[SUP] 3 [/SUP], Diabou Diagne[SUP] 3 [/SUP], Ndeye Coumba Toure Kane[SUP] 3 [/SUP], Gavin Cloherty[SUP] 4 [/SUP], Souleymane Mboup[SUP] 3 [/SUP]
Affiliations
- PMID: 34880295
- DOI: 10.1038/s41598-021-02874-z
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.