tetano
Editor, Senior Moderator
Sci Rep
. 2025 Feb 26;15(1):6833.
doi: 10.1038/s41598-025-91388-z. Factors associated with reduction in quality of life after SARS-CoV-2 infection
Christian Neumann[SUP] #[/SUP][SUP] 1 [/SUP], Tim J Hartung[SUP] #[/SUP][SUP] 2 3 [/SUP], Klara Boje[SUP] 4 [/SUP], Thomas Bahmer[SUP] 5 6 [/SUP], Julian Keil[SUP] 4 [/SUP], Wolfgang Lieb[SUP] 7 [/SUP], Katrin Franzpoetter[SUP] 7 [/SUP], Julius Welzel[SUP] 8 [/SUP], Irina Chaplinskaya-Sobol[SUP] 9 [/SUP], Matthias Endres[SUP] 2 10 11 12 13 14 [/SUP], Johanna Geritz[SUP] 8 [/SUP], Karl Georg Haeusler[SUP] 15 [/SUP], Peter Heuschmann[SUP] 16 17 18 [/SUP], Andreas Hinz[SUP] 3 [/SUP], Sina Hopff[SUP] 19 [/SUP], Anna Horn[SUP] 16 18 [/SUP], Carolin Nuernberger[SUP] 16 18 [/SUP], Lena Schmidbauer[SUP] 16 18 [/SUP], Michael Krawczak[SUP] 20 [/SUP], Anne-Kathrin Ruß[SUP] 7 20 [/SUP], Lilian Krist[SUP] 21 [/SUP], Thomas Keil[SUP] 22 [/SUP], Jennifer Kudelka[SUP] 8 [/SUP], Corina Maetzler[SUP] 8 [/SUP], Anja Mehnert-Theuerkauf[SUP] 3 [/SUP], Felipe A Montellano[SUP] 15 16 22 [/SUP], Caroline Morbach[SUP] 22 23 [/SUP], Sein Schmidt[SUP] 24 [/SUP], Jan Heyckendorf[SUP] 5 6 [/SUP], Flo Steigerwald[SUP] 2 [/SUP], Stefan Stoerk[SUP] 22 23 [/SUP], Christina Lemhoefer[SUP] 25 [/SUP], Stefan Schreiber[SUP] 5 [/SUP], Carsten Finke[SUP] #[/SUP][SUP] 2 [/SUP], Walter Maetzler[SUP] #[/SUP][SUP] 8 [/SUP]
Affiliations
Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but their causes and consequences are poorly understood. This prospective, population-based study examined associations between HrQoL and 49 demographic and clinical variables. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version in 3,475 participants (56% female; aged 18-88 years) approximately 9 months (baseline) and 26 months (follow-up) after their initial infection. Results were compared with the demographic and clinical variables using recursive feature elimination and random forest regression analyses. A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. Changes in HrQoL were associated with changes in fatigue, RS, and perceived stress, meaning that if these decreased from baseline to follow-up, then HrQoL was improved. However, it was not possible to predict whether an individual's HrQoL would improve or worsen 1 year later based on baseline variable scores. The aforementioned symptoms are specifically associated with impairment in the population's usual activities.
Keywords: Age; COVID-19; EQ-5D-5L; Fatigue; Post-acute COVID-19 syndrome; Quality of life.
. 2025 Feb 26;15(1):6833.
doi: 10.1038/s41598-025-91388-z. Factors associated with reduction in quality of life after SARS-CoV-2 infection
Christian Neumann[SUP] #[/SUP][SUP] 1 [/SUP], Tim J Hartung[SUP] #[/SUP][SUP] 2 3 [/SUP], Klara Boje[SUP] 4 [/SUP], Thomas Bahmer[SUP] 5 6 [/SUP], Julian Keil[SUP] 4 [/SUP], Wolfgang Lieb[SUP] 7 [/SUP], Katrin Franzpoetter[SUP] 7 [/SUP], Julius Welzel[SUP] 8 [/SUP], Irina Chaplinskaya-Sobol[SUP] 9 [/SUP], Matthias Endres[SUP] 2 10 11 12 13 14 [/SUP], Johanna Geritz[SUP] 8 [/SUP], Karl Georg Haeusler[SUP] 15 [/SUP], Peter Heuschmann[SUP] 16 17 18 [/SUP], Andreas Hinz[SUP] 3 [/SUP], Sina Hopff[SUP] 19 [/SUP], Anna Horn[SUP] 16 18 [/SUP], Carolin Nuernberger[SUP] 16 18 [/SUP], Lena Schmidbauer[SUP] 16 18 [/SUP], Michael Krawczak[SUP] 20 [/SUP], Anne-Kathrin Ruß[SUP] 7 20 [/SUP], Lilian Krist[SUP] 21 [/SUP], Thomas Keil[SUP] 22 [/SUP], Jennifer Kudelka[SUP] 8 [/SUP], Corina Maetzler[SUP] 8 [/SUP], Anja Mehnert-Theuerkauf[SUP] 3 [/SUP], Felipe A Montellano[SUP] 15 16 22 [/SUP], Caroline Morbach[SUP] 22 23 [/SUP], Sein Schmidt[SUP] 24 [/SUP], Jan Heyckendorf[SUP] 5 6 [/SUP], Flo Steigerwald[SUP] 2 [/SUP], Stefan Stoerk[SUP] 22 23 [/SUP], Christina Lemhoefer[SUP] 25 [/SUP], Stefan Schreiber[SUP] 5 [/SUP], Carsten Finke[SUP] #[/SUP][SUP] 2 [/SUP], Walter Maetzler[SUP] #[/SUP][SUP] 8 [/SUP]
Affiliations
- PMID: 40000883
- PMCID: PMC11861590
- DOI: 10.1038/s41598-025-91388-z
Long-term changes in health-related quality of life (HrQoL) after SARS-CoV-2 infection are common, but their causes and consequences are poorly understood. This prospective, population-based study examined associations between HrQoL and 49 demographic and clinical variables. HrQoL was assessed using the European Quality-of-Life-5-Dimensions-5-Level-Version in 3,475 participants (56% female; aged 18-88 years) approximately 9 months (baseline) and 26 months (follow-up) after their initial infection. Results were compared with the demographic and clinical variables using recursive feature elimination and random forest regression analyses. A statistically significant improvement in HrQoL was observed during the observation period. At baseline, 39% of the variance in HrQoL was explained by fatigue, muscle pain, number of remaining symptoms (RS), perceived stress, and age. At follow-up, fatigue, RS, perceived stress, muscle and joint pain, and age explained 54% of the variance in HrQoL. Changes in HrQoL were associated with changes in fatigue, RS, and perceived stress, meaning that if these decreased from baseline to follow-up, then HrQoL was improved. However, it was not possible to predict whether an individual's HrQoL would improve or worsen 1 year later based on baseline variable scores. The aforementioned symptoms are specifically associated with impairment in the population's usual activities.
Keywords: Age; COVID-19; EQ-5D-5L; Fatigue; Post-acute COVID-19 syndrome; Quality of life.