tetano
Editor, Senior Moderator
Sci Rep
. 2022 May 4;12(1):7247.
doi: 10.1038/s41598-022-10923-4.
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism
Isabel Espinosa-Salinas[SUP] #[/SUP][SUP] 1 [/SUP], Gonzalo Colmenarejo[SUP] #[/SUP][SUP] 2 [/SUP], Cristina M Fernández-Díaz[SUP] #[/SUP][SUP] 2 [/SUP], Marta Gómez de Cedrón[SUP] 2 [/SUP], J Alfredo Martinez[SUP] 2 3 4 [/SUP], Guillermo Reglero[SUP] 2 5 [/SUP], Ana Ramírez de Molina[SUP] 6 [/SUP]
Affiliations
Abstract
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
. 2022 May 4;12(1):7247.
doi: 10.1038/s41598-022-10923-4.
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism
Isabel Espinosa-Salinas[SUP] #[/SUP][SUP] 1 [/SUP], Gonzalo Colmenarejo[SUP] #[/SUP][SUP] 2 [/SUP], Cristina M Fernández-Díaz[SUP] #[/SUP][SUP] 2 [/SUP], Marta Gómez de Cedrón[SUP] 2 [/SUP], J Alfredo Martinez[SUP] 2 3 4 [/SUP], Guillermo Reglero[SUP] 2 5 [/SUP], Ana Ramírez de Molina[SUP] 6 [/SUP]
Affiliations
- PMID: 35508522
- DOI: 10.1038/s41598-022-10923-4
Abstract
The pandemic burden caused by the SARS-CoV-2 coronavirus constitutes a global public health emergency. Increasing understanding about predisposing factors to infection and severity is now a priority. Genetic, metabolic, and environmental factors can play a crucial role in the course and clinical outcome of COVID-19. We aimed to investigate the putative relationship between genetic factors associated to obesity, metabolism and lifestyle, and the presence and severity of SARS-CoV-2 infection. A total of 249 volunteers (178 women and 71 men, with mean and ± SD age of 49 ± 11 years) characterized for dietary, lifestyle habits and anthropometry, were studied for presence and severity of COVID-19 infection, and genotyped for 26 genetic variants related to obesity, lipid profile, inflammation, and biorhythm patterns. A statistically significant association was found concerning a protective effect of APOE rs7412 against SARS-CoV-2 infection (p = 0.039; OR 0.216; CI 0.084, 0.557) after correction for multiple comparisons. This protective effect was also ascribed to the APOɛ2 allele (p = 0.001; OR 0.207; CI 0.0796, 0.538). The genetic variant rs7412 resulting in ApoE2, genetic determinant of lipid and lipoprotein levels, could play a significant role protecting against SARS-CoV-2 infection.
