tetano
Editor, Senior Moderator
Sci Transl Med
. 2022 Jun 7;eabq3059.
doi: 10.1126/scitranslmed.abq3059. Online ahead of print.
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery
Justin J Frere[SUP] 1 2 [/SUP], Randal A Serafini[SUP] 3 [/SUP], Kerri D Pryce[SUP] 3 [/SUP], Marianna Zazhytska[SUP] 4 [/SUP], Kohei Oishi[SUP] 2 [/SUP], Ilona Golynker[SUP] 2 [/SUP], Maryline Panis[SUP] 2 [/SUP], Jeffrey Zimering[SUP] 3 5 [/SUP], Shu Horiuchi[SUP] 2 [/SUP], Daisy A Hoagland[SUP] 6 [/SUP], Rasmus Møller[SUP] 2 [/SUP], Anne Ruiz[SUP] 3 [/SUP], Albana Kodra[SUP] 4 [/SUP], Jonathan B Overdevest[SUP] 7 [/SUP], Peter D Canoll[SUP] 8 [/SUP], Alain C Borczuk[SUP] 9 [/SUP], Vasuretha Chandar[SUP] 10 [/SUP], Yaron Bram[SUP] 10 [/SUP], Robert Schwartz[SUP] 10 11 [/SUP], Stavros Lomvardas[SUP] 4 [/SUP], Venetia Zachariou[SUP] 3 [/SUP], Benjamin R tenOever[SUP] 2 [/SUP]
Affiliations
Abstract
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.
. 2022 Jun 7;eabq3059.
doi: 10.1126/scitranslmed.abq3059. Online ahead of print.
SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery
Justin J Frere[SUP] 1 2 [/SUP], Randal A Serafini[SUP] 3 [/SUP], Kerri D Pryce[SUP] 3 [/SUP], Marianna Zazhytska[SUP] 4 [/SUP], Kohei Oishi[SUP] 2 [/SUP], Ilona Golynker[SUP] 2 [/SUP], Maryline Panis[SUP] 2 [/SUP], Jeffrey Zimering[SUP] 3 5 [/SUP], Shu Horiuchi[SUP] 2 [/SUP], Daisy A Hoagland[SUP] 6 [/SUP], Rasmus Møller[SUP] 2 [/SUP], Anne Ruiz[SUP] 3 [/SUP], Albana Kodra[SUP] 4 [/SUP], Jonathan B Overdevest[SUP] 7 [/SUP], Peter D Canoll[SUP] 8 [/SUP], Alain C Borczuk[SUP] 9 [/SUP], Vasuretha Chandar[SUP] 10 [/SUP], Yaron Bram[SUP] 10 [/SUP], Robert Schwartz[SUP] 10 11 [/SUP], Stavros Lomvardas[SUP] 4 [/SUP], Venetia Zachariou[SUP] 3 [/SUP], Benjamin R tenOever[SUP] 2 [/SUP]
Affiliations
- PMID: 35857629
- DOI: 10.1126/scitranslmed.abq3059
Abstract
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in prolonged pathologies collectively referred to as post-acute sequalae of COVID-19 (PASC) or long COVID. To better understand the mechanism underlying long COVID biology, we compared the short- and long-term systemic responses in the golden hamster following either SARS-CoV-2 or influenza A virus (IAV) infection. Results demonstrated that SARS-CoV-2 exceeded IAV in its capacity to cause permanent injury to the lung and kidney and uniquely impacted the olfactory bulb (OB) and epithelium (OE). Despite a lack of detectable infectious virus, the OB and OE demonstrated myeloid and T cell activation, proinflammatory cytokine production, and an interferon response that correlated with behavioral changes extending a month post viral clearance. These sustained transcriptional changes could also be corroborated from tissue isolated from individuals who recovered from COVID-19. These data highlight a molecular mechanism for persistent COVID-19 symptomology and provide a small animal model to explore future therapeutics.