tetano
Editor, Senior Moderator
PLoS One. 2020 Feb 26;15(2):e0226936. doi: 10.1371/journal.pone.0226936. eCollection 2020. [h=1]Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure.[/h]
Glinge C[SUP]1,[/SUP][SUP]2[/SUP], Engstr?m T[SUP]1,[/SUP][SUP]3[/SUP], Midgley SE[SUP]4[/SUP], Tanck MWT[SUP]5[/SUP], Madsen JEH[SUP]1,[/SUP][SUP]6[/SUP], Pedersen F[SUP]1[/SUP], Ravn Jacobsen M[SUP]1[/SUP], Lodder EM[SUP]2[/SUP], Al-Hussainy NR[SUP]1[/SUP], Kj?r Stampe N[SUP]1[/SUP], Trebbien R[SUP]4[/SUP], K?ber L[SUP]1[/SUP], Gerds T[SUP]6[/SUP], Torp-Pedersen C[SUP]7,[/SUP][SUP]8[/SUP], K?lsen Fischer T[SUP]4,[/SUP][SUP]9[/SUP], Bezzina CR[SUP]2[/SUP], Tfelt-Hansen J[SUP]1,[/SUP][SUP]10[/SUP], Jabbari R[SUP]1,[/SUP][SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIMS:[/h] To investigate seasonality and association of increased enterovirus and influenza activity in the community with ventricular fibrillation (VF) risk during first ST-elevation myocardial infarction (STEMI).
[h=4]METHODS:[/h] This study comprised all consecutive patients with first STEMI (n = 4,659; aged 18-80 years) admitted to the invasive catheterization laboratory between 2010-2016, at Copenhagen University Hospital, Rigshospitalet, covering eastern Denmark (2.6 million inhabitants, 45% of the Danish population). Hospital admission, prescription, and vital status data were assessed using Danish nationwide registries. We utilized monthly/weekly surveillance data for enterovirus and influenza from the Danish National Microbiology Database (2010-2016) that receives copies of laboratory tests from all Danish departments of clinical microbiology.
[h=4]RESULTS:[/h] Of the 4,659 consecutively enrolled STEMI patients, 581 (12%) had VF before primary percutaneous coronary intervention. In a subset (n = 807), we found that VF patients experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with the patients without VF (OR 3.39, 95% CI 1.76-6.54). During the study period, 2,704 individuals were diagnosed with enterovirus and 19,742 with influenza. No significant association between enterovirus and VF (OR 1.00, 95% CI 0.99-1.02), influenza and VF (OR 1.00, 95% CI 1.00-1.00), or week number and VF (p-value 0.94 for enterovirus and 0.89 for influenza) was found.
[h=4]CONCLUSION:[/h] We found no clear seasonality of VF during first STEMI. Even though VF patients had experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with patients without VF, no relationship was found between enterovirus or influenza exposure and occurrence of VF.
PMID: 32101559 DOI: 10.1371/journal.pone.0226936
Glinge C[SUP]1,[/SUP][SUP]2[/SUP], Engstr?m T[SUP]1,[/SUP][SUP]3[/SUP], Midgley SE[SUP]4[/SUP], Tanck MWT[SUP]5[/SUP], Madsen JEH[SUP]1,[/SUP][SUP]6[/SUP], Pedersen F[SUP]1[/SUP], Ravn Jacobsen M[SUP]1[/SUP], Lodder EM[SUP]2[/SUP], Al-Hussainy NR[SUP]1[/SUP], Kj?r Stampe N[SUP]1[/SUP], Trebbien R[SUP]4[/SUP], K?ber L[SUP]1[/SUP], Gerds T[SUP]6[/SUP], Torp-Pedersen C[SUP]7,[/SUP][SUP]8[/SUP], K?lsen Fischer T[SUP]4,[/SUP][SUP]9[/SUP], Bezzina CR[SUP]2[/SUP], Tfelt-Hansen J[SUP]1,[/SUP][SUP]10[/SUP], Jabbari R[SUP]1,[/SUP][SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIMS:[/h] To investigate seasonality and association of increased enterovirus and influenza activity in the community with ventricular fibrillation (VF) risk during first ST-elevation myocardial infarction (STEMI).
[h=4]METHODS:[/h] This study comprised all consecutive patients with first STEMI (n = 4,659; aged 18-80 years) admitted to the invasive catheterization laboratory between 2010-2016, at Copenhagen University Hospital, Rigshospitalet, covering eastern Denmark (2.6 million inhabitants, 45% of the Danish population). Hospital admission, prescription, and vital status data were assessed using Danish nationwide registries. We utilized monthly/weekly surveillance data for enterovirus and influenza from the Danish National Microbiology Database (2010-2016) that receives copies of laboratory tests from all Danish departments of clinical microbiology.
[h=4]RESULTS:[/h] Of the 4,659 consecutively enrolled STEMI patients, 581 (12%) had VF before primary percutaneous coronary intervention. In a subset (n = 807), we found that VF patients experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with the patients without VF (OR 3.39, 95% CI 1.76-6.54). During the study period, 2,704 individuals were diagnosed with enterovirus and 19,742 with influenza. No significant association between enterovirus and VF (OR 1.00, 95% CI 0.99-1.02), influenza and VF (OR 1.00, 95% CI 1.00-1.00), or week number and VF (p-value 0.94 for enterovirus and 0.89 for influenza) was found.
[h=4]CONCLUSION:[/h] We found no clear seasonality of VF during first STEMI. Even though VF patients had experienced more generalized fatigue and flu-like symptoms within 7 days before STEMI compared with patients without VF, no relationship was found between enterovirus or influenza exposure and occurrence of VF.
PMID: 32101559 DOI: 10.1371/journal.pone.0226936