tetano
Editor, Senior Moderator
Sci Rep. 2016 Nov 28;6:37915. doi: 10.1038/srep37915.
[h=1]Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus.[/h] Yasui F[SUP]1[/SUP], Itoh Y[SUP]2[/SUP], Ikejiri A[SUP]1[/SUP], Kitabatake M[SUP]3[/SUP], Sakaguchi N[SUP]1,[/SUP][SUP]4[/SUP], Munekata K[SUP]1[/SUP], Shichinohe S[SUP]2[/SUP], Hayashi Y[SUP]1[/SUP], Ishigaki H[SUP]2[/SUP], Nakayama M[SUP]2[/SUP], Sakoda Y[SUP]5[/SUP], Kida H[SUP]5[/SUP], Ogasawara K[SUP]2[/SUP], Kohara M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5N1 highly pathogenic avian influenza (H5N1 HPAI) virus causes elevated mortality compared with seasonal influenza viruses like H1N1 pandemic influenza (H1N1 pdm) virus. We identified a mechanism associated with the severe symptoms seen with H5N1 HPAI virus infection. H5N1 HPAI virus infection induced a decrease of dendritic cell number in the splenic extrafollicular T-cell zone and impaired formation of the outer layers of B-cell follicles, resulting in insufficient levels of antibody production after infection. However, in animals vaccinated with a live recombinant vaccinia virus expressing the H5 hemagglutinin, infection with H5N1 HPAI virus induced parafollicular dendritic cell accumulation and efficient antibody production. These results indicate that a recombinant vaccinia encoding H5 hemagglutinin gene does not impair dendritic cell recruitment and can be a useful vaccine candidate.
PMID: 27892498 DOI: 10.1038/srep37915
[PubMed - in process] Free full text
[h=1]Sensitization with vaccinia virus encoding H5N1 hemagglutinin restores immune potential against H5N1 influenza virus.[/h] Yasui F[SUP]1[/SUP], Itoh Y[SUP]2[/SUP], Ikejiri A[SUP]1[/SUP], Kitabatake M[SUP]3[/SUP], Sakaguchi N[SUP]1,[/SUP][SUP]4[/SUP], Munekata K[SUP]1[/SUP], Shichinohe S[SUP]2[/SUP], Hayashi Y[SUP]1[/SUP], Ishigaki H[SUP]2[/SUP], Nakayama M[SUP]2[/SUP], Sakoda Y[SUP]5[/SUP], Kida H[SUP]5[/SUP], Ogasawara K[SUP]2[/SUP], Kohara M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] H5N1 highly pathogenic avian influenza (H5N1 HPAI) virus causes elevated mortality compared with seasonal influenza viruses like H1N1 pandemic influenza (H1N1 pdm) virus. We identified a mechanism associated with the severe symptoms seen with H5N1 HPAI virus infection. H5N1 HPAI virus infection induced a decrease of dendritic cell number in the splenic extrafollicular T-cell zone and impaired formation of the outer layers of B-cell follicles, resulting in insufficient levels of antibody production after infection. However, in animals vaccinated with a live recombinant vaccinia virus expressing the H5 hemagglutinin, infection with H5N1 HPAI virus induced parafollicular dendritic cell accumulation and efficient antibody production. These results indicate that a recombinant vaccinia encoding H5 hemagglutinin gene does not impair dendritic cell recruitment and can be a useful vaccine candidate.
PMID: 27892498 DOI: 10.1038/srep37915
[PubMed - in process] Free full text