tetano
Editor, Senior Moderator
Signal Transduct Target Ther
. 2024 May 29;9(1):141.
doi: 10.1038/s41392-024-01867-4. Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection
Gang Yang[SUP] #[/SUP][SUP] 1 2 [/SUP], Jinpeng Cao[SUP] #[/SUP][SUP] 2 3 [/SUP], Jian Qin[SUP] #[/SUP][SUP] 1 [/SUP], Xinyue Mei[SUP] #[/SUP][SUP] 2 3 [/SUP], Shidong Deng[SUP] 2 3 [/SUP], Yingjiao Xia[SUP] 1 [/SUP], Jun Zhao[SUP] 1 [/SUP], Junxiang Wang[SUP] 2 3 [/SUP], Tao Luan[SUP] 1 2 [/SUP], Daxiang Chen[SUP] 2 3 [/SUP], Peiyu Huang[SUP] 2 3 [/SUP], Cheng Chen[SUP] 1 [/SUP], Xi Sun[SUP] 2 3 [/SUP], Qi Luo[SUP] 2 3 [/SUP], Jie Su[SUP] 2 3 [/SUP], Yunhui Zhang[SUP] 4 [/SUP], Nanshan Zhong[SUP] 5 6 7 [/SUP], Zhongfang Wang[SUP] 8 9 [/SUP]
Affiliations
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain unclarified. Here, we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by severity. We found that early and robust SARS-CoV-2-specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cell responses ameliorate disease progression and shortened hospital stay, while delayed and attenuated virus-specific CD8[SUP]+[/SUP] T cell responses are prominent severe COVID-19 features. Delayed antiviral antibody generation rather than titer level associates with severe outcomes. Conversely, initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity, demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate counterparts. Moreover, initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection risk. Overall, our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.
. 2024 May 29;9(1):141.
doi: 10.1038/s41392-024-01867-4. Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection
Gang Yang[SUP] #[/SUP][SUP] 1 2 [/SUP], Jinpeng Cao[SUP] #[/SUP][SUP] 2 3 [/SUP], Jian Qin[SUP] #[/SUP][SUP] 1 [/SUP], Xinyue Mei[SUP] #[/SUP][SUP] 2 3 [/SUP], Shidong Deng[SUP] 2 3 [/SUP], Yingjiao Xia[SUP] 1 [/SUP], Jun Zhao[SUP] 1 [/SUP], Junxiang Wang[SUP] 2 3 [/SUP], Tao Luan[SUP] 1 2 [/SUP], Daxiang Chen[SUP] 2 3 [/SUP], Peiyu Huang[SUP] 2 3 [/SUP], Cheng Chen[SUP] 1 [/SUP], Xi Sun[SUP] 2 3 [/SUP], Qi Luo[SUP] 2 3 [/SUP], Jie Su[SUP] 2 3 [/SUP], Yunhui Zhang[SUP] 4 [/SUP], Nanshan Zhong[SUP] 5 6 7 [/SUP], Zhongfang Wang[SUP] 8 9 [/SUP]
Affiliations
- PMID: 38811527
- DOI: 10.1038/s41392-024-01867-4
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain unclarified. Here, we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by severity. We found that early and robust SARS-CoV-2-specific CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cell responses ameliorate disease progression and shortened hospital stay, while delayed and attenuated virus-specific CD8[SUP]+[/SUP] T cell responses are prominent severe COVID-19 features. Delayed antiviral antibody generation rather than titer level associates with severe outcomes. Conversely, initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity, demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate counterparts. Moreover, initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection risk. Overall, our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.