tetano
Editor, Senior Moderator
Vaccine. 2018 Jul 26. pii: S0264-410X(18)30987-3. doi: 10.1016/j.vaccine.2018.07.021. [Epub ahead of print]
[h=1]Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007-2014.[/h] Noh JY[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Song JY[SUP]1[/SUP], Lee HS[SUP]2[/SUP], Lim S[SUP]2[/SUP], Lee J[SUP]3[/SUP], Seo YB[SUP]3[/SUP], Lee JS[SUP]4[/SUP], Wie SH[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Heo JY[SUP]6[/SUP], Kim YK[SUP]7[/SUP], Park KH[SUP]8[/SUP], Kim SW[SUP]9[/SUP], Lee SH[SUP]10[/SUP], Lee JH[SUP]11[/SUP], Kim DH[SUP]12[/SUP], Woo SI[SUP]13[/SUP], Lim CS[SUP]14[/SUP], Cho KS[SUP]15[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]16[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007-2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007-2008 season to 2013-2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009-2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007-2008, 2011-2012, and 2013-2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
[h=4]KEYWORDS:[/h] Epidemiology; Influenza B virus
PMID: 30057284 DOI: 10.1016/j.vaccine.2018.07.021
[h=1]Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007-2014.[/h] Noh JY[SUP]1[/SUP], Choi WS[SUP]1[/SUP], Song JY[SUP]1[/SUP], Lee HS[SUP]2[/SUP], Lim S[SUP]2[/SUP], Lee J[SUP]3[/SUP], Seo YB[SUP]3[/SUP], Lee JS[SUP]4[/SUP], Wie SH[SUP]5[/SUP], Jeong HW[SUP]6[/SUP], Heo JY[SUP]6[/SUP], Kim YK[SUP]7[/SUP], Park KH[SUP]8[/SUP], Kim SW[SUP]9[/SUP], Lee SH[SUP]10[/SUP], Lee JH[SUP]11[/SUP], Kim DH[SUP]12[/SUP], Woo SI[SUP]13[/SUP], Lim CS[SUP]14[/SUP], Cho KS[SUP]15[/SUP], Cheong HJ[SUP]1[/SUP], Kim WJ[SUP]16[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007-2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007-2008 season to 2013-2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009-2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007-2008, 2011-2012, and 2013-2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.
[h=4]KEYWORDS:[/h] Epidemiology; Influenza B virus
PMID: 30057284 DOI: 10.1016/j.vaccine.2018.07.021