tetano
Editor, Senior Moderator
J Neuroimmunol. 2012 Jan 11. [Epub ahead of print]
Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.
Mays JW, Powell ND, Hunzeker JT, Hanke ML, Bailey MT, Sheridan JF.
Source
The Ohio State University, College of Dentistry, Section of Oral Biology, Columbus, OH, USA.
Abstract
Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner. However, the effect of SDR on the primary anti-viral immune response has not been elucidated. In this study, SDR-infected (INF) mice terminated viral gene expression earlier and mounted an enhanced pulmonary IAV-specific CD8(+)T cell response versus controls. Additionally, SDR-INF mice had a more pro-inflammatory lung profile prior to and during infection and an attenuated corticosterone response. These data demonstrate neuroendocrine modification of the lung microenvironment and increased antigen-specific T cell activation, clonal expansion and viral control in stress-exposed mice.
Copyright ? 2011. Published by Elsevier B.V.
PMID:
22244573
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22244573
Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.
Mays JW, Powell ND, Hunzeker JT, Hanke ML, Bailey MT, Sheridan JF.
Source
The Ohio State University, College of Dentistry, Section of Oral Biology, Columbus, OH, USA.
Abstract
Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner. However, the effect of SDR on the primary anti-viral immune response has not been elucidated. In this study, SDR-infected (INF) mice terminated viral gene expression earlier and mounted an enhanced pulmonary IAV-specific CD8(+)T cell response versus controls. Additionally, SDR-INF mice had a more pro-inflammatory lung profile prior to and during infection and an attenuated corticosterone response. These data demonstrate neuroendocrine modification of the lung microenvironment and increased antigen-specific T cell activation, clonal expansion and viral control in stress-exposed mice.
Copyright ? 2011. Published by Elsevier B.V.
PMID:
22244573
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22244573