Mary Wilson
Well-known member
October 19 2022
Jonathan E. Pekar, Spyros Lytras, Andrew Magee, Jennifer L. Havens, Edyth Parker, Simon Dellicour, Joseph Hughes, Tetyana I. Vasylyeva, Philippe Lemey, David L. Robertson, Michael Worobey, Joel O. Wertheim
Introduction
Horseshoe bats are the likely reservoir of sarbecoviruses (1), including SARS-CoV-1 and SARS-CoV-2 (2–4). Since the emergence of SARS-CoV-1 in 2002 and SARS-CoV-2 in 2019, there has been an increase in the sampling of sarbecoviruses in bats, which can reveal how recently SARS-CoV-1-like and SARS-CoV-2-like viruses sampled in bats shared a common ancestor with, respectively, SARS-CoV-1 and SARS-CoV-2 (jointly referred to as SARS-CoVs). Genome-wide sequence identity is typically used to compare sarbecoviruses to the SARS-CoVs, but, because sarbecoviruses frequently recombine (5, 6), whole genome identity is likely an insufficient method to determine their recent evolutionary histories. Rather, it is the non-recombinant regions (NRRs) of SARS-CoVs that are most informative of the origins of these viruses. Here, we analyze the recombination patterns of the clade of SARS-CoV-1-like viruses and the clade of SARS-CoV-2-like viruses and their respective evolutionary histories. We find that the available sequence data provide evidence of an ancestor of each SARS-CoV circulating in bats only a few years prior to its emergence.
https://virological.org/t/the-compa...al-ancestors-of-sars-cov-1-and-sars-cov-2/906
Jonathan E. Pekar, Spyros Lytras, Andrew Magee, Jennifer L. Havens, Edyth Parker, Simon Dellicour, Joseph Hughes, Tetyana I. Vasylyeva, Philippe Lemey, David L. Robertson, Michael Worobey, Joel O. Wertheim
Introduction
Horseshoe bats are the likely reservoir of sarbecoviruses (1), including SARS-CoV-1 and SARS-CoV-2 (2–4). Since the emergence of SARS-CoV-1 in 2002 and SARS-CoV-2 in 2019, there has been an increase in the sampling of sarbecoviruses in bats, which can reveal how recently SARS-CoV-1-like and SARS-CoV-2-like viruses sampled in bats shared a common ancestor with, respectively, SARS-CoV-1 and SARS-CoV-2 (jointly referred to as SARS-CoVs). Genome-wide sequence identity is typically used to compare sarbecoviruses to the SARS-CoVs, but, because sarbecoviruses frequently recombine (5, 6), whole genome identity is likely an insufficient method to determine their recent evolutionary histories. Rather, it is the non-recombinant regions (NRRs) of SARS-CoVs that are most informative of the origins of these viruses. Here, we analyze the recombination patterns of the clade of SARS-CoV-1-like viruses and the clade of SARS-CoV-2-like viruses and their respective evolutionary histories. We find that the available sequence data provide evidence of an ancestor of each SARS-CoV circulating in bats only a few years prior to its emergence.
https://virological.org/t/the-compa...al-ancestors-of-sars-cov-1-and-sars-cov-2/906