tetano
Editor, Senior Moderator
Crit Care. 2012 Nov 6;16(6):168. [Epub ahead of print]
The host response to infection: advancing a novel diagnostic paradigm.
Ginsburg GS, Woods CW.
Source
Institute for Genome Sciences & Policy, 101 Science Drive, Duke University, Durham, NC 27710, USA. geoffrey.ginsburg@duke.edu.
Abstract
ABSTRACT: Capturing the host response by using genomic technologies such as transcriptional profiling provides a new paradigm for classifying and diagnosing infectious disease and for potentially distinguishing infection from other causes of serious respiratory illness. This strategy has been used to define a blood-based RNA signature as a classifier for pandemic H1N1 influenza infection that is distinct from bacterial pneumonia and other inflammatory causes of respiratory disease. To realize the full potential of this approach as a diagnostic test will require additional independent validation of the results and studies to examine the specificity of this signature for viral versus bacterial infection or co-infection.
PMID:
23134694
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23134694
The host response to infection: advancing a novel diagnostic paradigm.
Ginsburg GS, Woods CW.
Source
Institute for Genome Sciences & Policy, 101 Science Drive, Duke University, Durham, NC 27710, USA. geoffrey.ginsburg@duke.edu.
Abstract
ABSTRACT: Capturing the host response by using genomic technologies such as transcriptional profiling provides a new paradigm for classifying and diagnosing infectious disease and for potentially distinguishing infection from other causes of serious respiratory illness. This strategy has been used to define a blood-based RNA signature as a classifier for pandemic H1N1 influenza infection that is distinct from bacterial pneumonia and other inflammatory causes of respiratory disease. To realize the full potential of this approach as a diagnostic test will require additional independent validation of the results and studies to examine the specificity of this signature for viral versus bacterial infection or co-infection.
PMID:
23134694
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23134694