tetano
Editor, Senior Moderator
Braz J Infect Dis. 2018 Oct 31. pii: S1413-8670(18)30525-7. doi: 10.1016/j.bjid.2018.10.275. [Epub ahead of print]
[h=1]The influenza season 2016/17 in Bucharest, Romania - surveillance data and clinical characteristics of patients with influenza-like illness admitted to a tertiary infectious diseases hospital.[/h] Drăgănescu A[SUP]1[/SUP], Săndulescu O[SUP]2[/SUP], Florea D[SUP]3[/SUP], Vlaicu O[SUP]1[/SUP], Streinu-Cercel A[SUP]3[/SUP], Oţelea D[SUP]1[/SUP], Aramă V[SUP]3[/SUP], Luminos ML[SUP]3[/SUP], Streinu-Cercel A[SUP]3[/SUP], Niţescu M[SUP]3[/SUP], Ivanciuc A[SUP]4[/SUP], Bacruban R[SUP]1[/SUP], Piţigoi D[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage.
[h=4]OBJECTIVES:[/h] To describe the influenza cases and viral circulation among hospitalized patients.
[h=4]METHODS:[/h] A prospective study based on active surveillance of inpatients with influenza-like illness (ILI) from a tertiary hospital in Bucharest, Romania, in the season 2016/17.
[h=4]RESULTS:[/h] A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3-13 years and >65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: a viruses were replaced by B viruses from week 9/2017; B viruses predominated (66.1%). Among the 133 (69.3%) subtyped samples, all influenza A were subtype H3 (n=57) and all influenza B were B/Victoria (n=76). Patients who tested positive for influenza presented fewer comorbidities (p=0.012), except for the elderly, in whom influenza was more common in patients with comorbidities (p=0.050). DISEASE: outcome was generally favorable on antiviral treatment. The length of hospital stay was slightly longer in ILI patients negative for influenza (p=0.031).
[h=4]CONCLUSIONS:[/h] Distinctive co-circulation of A/H3 and B/Victoria in Bucharest, Romania in the 2016/17 influenza season was found. While the A/H3 subtype was predominant throughout Europe that season, B/Victoria appears to have circulated specifically in Romania and the Eastern European region, predominantly affecting preschoolers and school children.
Copyright ? 2018. Published by Elsevier Espa?a, S.L.U.
[h=4]KEYWORDS:[/h] A/H3; B/Victoria; ILI; Influenza; SARI; Subtype
PMID: 30391275 DOI: 10.1016/j.bjid.2018.10.275
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[h=1]The influenza season 2016/17 in Bucharest, Romania - surveillance data and clinical characteristics of patients with influenza-like illness admitted to a tertiary infectious diseases hospital.[/h] Drăgănescu A[SUP]1[/SUP], Săndulescu O[SUP]2[/SUP], Florea D[SUP]3[/SUP], Vlaicu O[SUP]1[/SUP], Streinu-Cercel A[SUP]3[/SUP], Oţelea D[SUP]1[/SUP], Aramă V[SUP]3[/SUP], Luminos ML[SUP]3[/SUP], Streinu-Cercel A[SUP]3[/SUP], Niţescu M[SUP]3[/SUP], Ivanciuc A[SUP]4[/SUP], Bacruban R[SUP]1[/SUP], Piţigoi D[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza continues to drive seasonal morbidity, particularly in settings with low vaccine coverage.
[h=4]OBJECTIVES:[/h] To describe the influenza cases and viral circulation among hospitalized patients.
[h=4]METHODS:[/h] A prospective study based on active surveillance of inpatients with influenza-like illness (ILI) from a tertiary hospital in Bucharest, Romania, in the season 2016/17.
[h=4]RESULTS:[/h] A total of 446 patients were tested, with a balanced gender distribution. Overall, 192 (43%) patients tested positive for influenza, with the highest positivity rate in the age groups 3-13 years and >65 years. Peak activity occurred between weeks 1 and 16/2017, with biphasic distribution: a viruses were replaced by B viruses from week 9/2017; B viruses predominated (66.1%). Among the 133 (69.3%) subtyped samples, all influenza A were subtype H3 (n=57) and all influenza B were B/Victoria (n=76). Patients who tested positive for influenza presented fewer comorbidities (p=0.012), except for the elderly, in whom influenza was more common in patients with comorbidities (p=0.050). DISEASE: outcome was generally favorable on antiviral treatment. The length of hospital stay was slightly longer in ILI patients negative for influenza (p=0.031).
[h=4]CONCLUSIONS:[/h] Distinctive co-circulation of A/H3 and B/Victoria in Bucharest, Romania in the 2016/17 influenza season was found. While the A/H3 subtype was predominant throughout Europe that season, B/Victoria appears to have circulated specifically in Romania and the Eastern European region, predominantly affecting preschoolers and school children.
Copyright ? 2018. Published by Elsevier Espa?a, S.L.U.
[h=4]KEYWORDS:[/h] A/H3; B/Victoria; ILI; Influenza; SARI; Subtype
PMID: 30391275 DOI: 10.1016/j.bjid.2018.10.275
Free full text