Giuseppe
Emeritus
[Source: The Lancet Respiratory Medicine, full page: (LINK). Abstract, edited.]
The Lancet Respiratory Medicine, Early Online Publication, 19 August 2013
doi:10.1016/S2213-2600(13)70134-6
Copyright ? 2013 Elsevier Ltd All rights reserved.
Future clinical applications of genomics for acute respiratory distress syndrome
Original Text
Dr Nuala J Meyer MD a
Summary
Acute respiratory distress syndrome remains a substantial cause of morbidity and mortality in intensive care units, yet no specific pharmacotherapy has proven useful in reducing the duration of mechanical ventilation or improving survival. One factor that might hamper the development of treatment for acute respiratory distress syndrome is the heterogeneous nature of the population who present with the syndrome. In this Review, the potential of genomic approaches?genetic association, gene expression, metabolomic, proteomic, and systems biology applications?for the identification of molecular endotypes within acute respiratory distress syndrome and potentially for the prediction, diagnosis, prognosis, and treatment of this difficult disorder are discussed.
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a Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
Correspondence to: Dr Nuala Meyer, Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 3600 Spruce Street, 8026 Maloney Building, Philadelphia, PA 19104, USA
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The Lancet Respiratory Medicine, Early Online Publication, 19 August 2013
doi:10.1016/S2213-2600(13)70134-6
Copyright ? 2013 Elsevier Ltd All rights reserved.
Future clinical applications of genomics for acute respiratory distress syndrome
Original Text
Dr Nuala J Meyer MD a
Summary
Acute respiratory distress syndrome remains a substantial cause of morbidity and mortality in intensive care units, yet no specific pharmacotherapy has proven useful in reducing the duration of mechanical ventilation or improving survival. One factor that might hamper the development of treatment for acute respiratory distress syndrome is the heterogeneous nature of the population who present with the syndrome. In this Review, the potential of genomic approaches?genetic association, gene expression, metabolomic, proteomic, and systems biology applications?for the identification of molecular endotypes within acute respiratory distress syndrome and potentially for the prediction, diagnosis, prognosis, and treatment of this difficult disorder are discussed.
________
a Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA, USA
Correspondence to: Dr Nuala Meyer, Department of Medicine Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, 3600 Spruce Street, 8026 Maloney Building, Philadelphia, PA 19104, USA
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