Mary Wilson
Well-known member
Published: November 2, 2022
https://doi.org/10.1371/journal.ppat.1010915
Anuradha Rajamanickam, Pavan Kumar Nathella, Aishwarya Venkatarama, Poovazhagi Varadarjan, Srinithi Kannan, Arul Nancy Pandiarajan, Rachel Mariam Renji, Elayarani Elavarasan,Akshith Thimmaiah, Kandasamy Sasidaran, Nedunchelian Krishnamoorthy, Suresh Natarajan, Ganesh Ramaswamy, [ ... ], Subash Babu [ view all ]
Abstract
The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters with the aim of distinguishing MIS-C from other syndromes with overlapping clinical presentations. MIS-C children differed from children with non-MIS-C conditions by having increased numbers of naïve CD8[SUP]+[/SUP] T cells, naïve, immature and atypical memory B cells and diminished numbers of transitional memory, stem cell memory, central and effector memory CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cells, classical, activated memory B and plasma cells and monocyte (intermediate and non-classical) and dendritic cell (plasmacytoid and myeloid) subsets. All of the above alterations were significantly reversed at 6–9 months post-recovery in MIS-C. Thus, MIS-C is characterized by a distinct cellular signature that distinguishes it from other syndromes with overlapping clinical presentations.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010915#sec002
https://doi.org/10.1371/journal.ppat.1010915
Anuradha Rajamanickam, Pavan Kumar Nathella, Aishwarya Venkatarama, Poovazhagi Varadarjan, Srinithi Kannan, Arul Nancy Pandiarajan, Rachel Mariam Renji, Elayarani Elavarasan,Akshith Thimmaiah, Kandasamy Sasidaran, Nedunchelian Krishnamoorthy, Suresh Natarajan, Ganesh Ramaswamy, [ ... ], Subash Babu [ view all ]
Abstract
The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters with the aim of distinguishing MIS-C from other syndromes with overlapping clinical presentations. MIS-C children differed from children with non-MIS-C conditions by having increased numbers of naïve CD8[SUP]+[/SUP] T cells, naïve, immature and atypical memory B cells and diminished numbers of transitional memory, stem cell memory, central and effector memory CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T cells, classical, activated memory B and plasma cells and monocyte (intermediate and non-classical) and dendritic cell (plasmacytoid and myeloid) subsets. All of the above alterations were significantly reversed at 6–9 months post-recovery in MIS-C. Thus, MIS-C is characterized by a distinct cellular signature that distinguishes it from other syndromes with overlapping clinical presentations.
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010915#sec002