tetano
Editor, Senior Moderator
Biochem J. 2019 Mar 27;476(6):1005-1008. doi: 10.1042/BCJ20190018.
[h=1]Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.[/h] Villal?n-Letelier F[SUP]1[/SUP], Reading PC[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Moloney leukemia virus 10 (MOV10) is an interferon-inducible RNA helicase that has been implicated in a broad range of cellular functions, including modulating the replication of a diverse range of viruses. However, the mechanisms by which MOV10 promotes or inhibits the replication of particular viruses have not been well defined. A recent paper published in the Biochemical Journal by Li et al. [Biochem. J. (2019) 476, 467-481] provides insight regarding the mechanisms by which MOV10 restricts influenza A virus (IAV) infection in host cells. First, the authors confirm that MOV10 binds to the viral nucleoprotein (NP) and sequesters the viral ribonucleoprotein complex in cytoplasmic granules called processing (P)-bodies, thus inhibiting IAV replication. Second, they demonstrate that the non-structural (NS)1 protein of IAV can act as an antagonist of MOV10, inhibiting the association of MOV10 with NP and promoting MOV10 degradation through the lysosomal pathway. Further research will determine if cellular RNA helicases such as MOV10 represent suitable targets for the development of novel anti-IAV therapies.
? 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
[h=4]KEYWORDS:[/h] RNA helicase; antiviral; influenza
PMID: 30918067 DOI: 10.1042/BCJ20190018
[h=1]Unraveling the role of the MOV10 RNA helicase during influenza A virus infection.[/h] Villal?n-Letelier F[SUP]1[/SUP], Reading PC[SUP]2,[/SUP][SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Moloney leukemia virus 10 (MOV10) is an interferon-inducible RNA helicase that has been implicated in a broad range of cellular functions, including modulating the replication of a diverse range of viruses. However, the mechanisms by which MOV10 promotes or inhibits the replication of particular viruses have not been well defined. A recent paper published in the Biochemical Journal by Li et al. [Biochem. J. (2019) 476, 467-481] provides insight regarding the mechanisms by which MOV10 restricts influenza A virus (IAV) infection in host cells. First, the authors confirm that MOV10 binds to the viral nucleoprotein (NP) and sequesters the viral ribonucleoprotein complex in cytoplasmic granules called processing (P)-bodies, thus inhibiting IAV replication. Second, they demonstrate that the non-structural (NS)1 protein of IAV can act as an antagonist of MOV10, inhibiting the association of MOV10 with NP and promoting MOV10 degradation through the lysosomal pathway. Further research will determine if cellular RNA helicases such as MOV10 represent suitable targets for the development of novel anti-IAV therapies.
? 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
[h=4]KEYWORDS:[/h] RNA helicase; antiviral; influenza
PMID: 30918067 DOI: 10.1042/BCJ20190018