tetano
Editor, Senior Moderator
Scand J Immunol. 2015 Dec 30. doi: 10.1111/sji.12410. [Epub ahead of print]
[h=1]Vaccine induced antibody responses prevent the induction of Interferon type I responses upon a homotypic live virus challenge.[/h] Chan J[SUP]1[/SUP], Babb R[SUP]1[/SUP], David SC[SUP]1[/SUP], McColl SR[SUP]1[/SUP], Alsharifi M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During acute viral infections, innate immunity provides essential protective measures to minimise virus dissemination and regulate adaptive immunity. This helps to successfully eliminate the pathogen and establish long-term memory. Here, we investigated the effect of vaccine induced antibody responses on the induction of IFN-I responses and the associated lymphocyte activation using influenza A virus vaccination and challenge models. Mice were vaccinated with gamma-irradiated influenza A virus (γ-FLU) and challenged three weeks later with live virus. Our data shows a significant reduction in IFN-I responses and lymphocyte activation following a homotypic virus challenge. We confirmed the role of vaccine-induced antibody responses in the observed impairment of IFN-I and the associated lymphocyte activation using adoptive transfer of immune sera and administration of sera-treated viruses prior to challenge. Overall, we addressed a fundamental concept in immunology and provided experimental data illustrating the inhibition of IFN-I responses in vaccinated animals upon a homotypic virus challenge. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Vaccination; antibodies; innate immunity; viral infections
PMID: 26715418 [PubMed - as supplied by publisher]
[h=1]Vaccine induced antibody responses prevent the induction of Interferon type I responses upon a homotypic live virus challenge.[/h] Chan J[SUP]1[/SUP], Babb R[SUP]1[/SUP], David SC[SUP]1[/SUP], McColl SR[SUP]1[/SUP], Alsharifi M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] During acute viral infections, innate immunity provides essential protective measures to minimise virus dissemination and regulate adaptive immunity. This helps to successfully eliminate the pathogen and establish long-term memory. Here, we investigated the effect of vaccine induced antibody responses on the induction of IFN-I responses and the associated lymphocyte activation using influenza A virus vaccination and challenge models. Mice were vaccinated with gamma-irradiated influenza A virus (γ-FLU) and challenged three weeks later with live virus. Our data shows a significant reduction in IFN-I responses and lymphocyte activation following a homotypic virus challenge. We confirmed the role of vaccine-induced antibody responses in the observed impairment of IFN-I and the associated lymphocyte activation using adoptive transfer of immune sera and administration of sera-treated viruses prior to challenge. Overall, we addressed a fundamental concept in immunology and provided experimental data illustrating the inhibition of IFN-I responses in vaccinated animals upon a homotypic virus challenge. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Vaccination; antibodies; innate immunity; viral infections
PMID: 26715418 [PubMed - as supplied by publisher]