tetano
Editor, Senior Moderator
Virol J
. 2024 Sep 9;21(1):212.
doi: 10.1186/s12985-024-02484-x. Outcomes of COVID-19 in patients with obinutuzumab compared with patients with rituximab: a retrospective cohort study
Wenxiu Shu[SUP] #[/SUP][SUP] 1 [/SUP], Qianqian Yang[SUP] #[/SUP][SUP] 1 [/SUP], Jing Le[SUP] 1 [/SUP], Qianqian Cai[SUP] 1 [/SUP], Hui Dai[SUP] 1 [/SUP], Liufei Luo[SUP] 1 [/SUP], Jiaqi Tong[SUP] 1 [/SUP], Yanping Song[SUP] 1 [/SUP], Bingrong Chen[SUP] 1 [/SUP], Dengbing Chen[SUP] 1 [/SUP], Dian Jin[SUP] 2 [/SUP]
Affiliations
Background: Patients treated with anti-CD20 monoclonal antibodies could have a higher risk of adverse outcomes of coronavirus disease 2019 (COVID-19). The novel anti-CD20 monoclonal antibody obinutuzumab has shown greater B-cell depletion and superior in vitro efficacy than rituximab. We aimed to assess whether obinutuzumab would result in worse COVID-19 outcomes than rituximab.
Methods: We retrospectively reviewed 124 patients with B-cell lymphoma, 106 of whom received rituximab treatment and 18 of whom received obinutuzumab treatment. The adverse outcomes of COVID-19 were compared between patients in the two cohorts.
Results: The proportions of patients who were hospitalized (55.6% vs. 20.8%, p = 0.005), experienced prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (38.9% vs. 2.9%, p < 0.001), and developed severe COVID-19 (33.3% vs. 4.7%, p < 0.001) were higher in patients with obinutuzumab than in those with rituximab. Multivariate analyses showed that obinuzumab treatment was associated with higher incidences of prolonged SARS-CoV-2 infection (OR 27.05, 95% CI 3.75-195.22, p = 0.001) and severe COVID-19(OR 15.07, 95% CI 2.58-91.72, p = 0.003).
Conclusions: Our study suggested that patients treated with obinutuzumab had a higher risk of prolonged SARS-CoV-2 infection and severe COVID-19 than those treated with rituximab.
Keywords: COVID-19; Lymphoma; Obinutuzumab; Prolonged SARS-CoV-2 infection; Rituximab.
. 2024 Sep 9;21(1):212.
doi: 10.1186/s12985-024-02484-x. Outcomes of COVID-19 in patients with obinutuzumab compared with patients with rituximab: a retrospective cohort study
Wenxiu Shu[SUP] #[/SUP][SUP] 1 [/SUP], Qianqian Yang[SUP] #[/SUP][SUP] 1 [/SUP], Jing Le[SUP] 1 [/SUP], Qianqian Cai[SUP] 1 [/SUP], Hui Dai[SUP] 1 [/SUP], Liufei Luo[SUP] 1 [/SUP], Jiaqi Tong[SUP] 1 [/SUP], Yanping Song[SUP] 1 [/SUP], Bingrong Chen[SUP] 1 [/SUP], Dengbing Chen[SUP] 1 [/SUP], Dian Jin[SUP] 2 [/SUP]
Affiliations
- PMID: 39252096
- DOI: 10.1186/s12985-024-02484-x
Background: Patients treated with anti-CD20 monoclonal antibodies could have a higher risk of adverse outcomes of coronavirus disease 2019 (COVID-19). The novel anti-CD20 monoclonal antibody obinutuzumab has shown greater B-cell depletion and superior in vitro efficacy than rituximab. We aimed to assess whether obinutuzumab would result in worse COVID-19 outcomes than rituximab.
Methods: We retrospectively reviewed 124 patients with B-cell lymphoma, 106 of whom received rituximab treatment and 18 of whom received obinutuzumab treatment. The adverse outcomes of COVID-19 were compared between patients in the two cohorts.
Results: The proportions of patients who were hospitalized (55.6% vs. 20.8%, p = 0.005), experienced prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (38.9% vs. 2.9%, p < 0.001), and developed severe COVID-19 (33.3% vs. 4.7%, p < 0.001) were higher in patients with obinutuzumab than in those with rituximab. Multivariate analyses showed that obinuzumab treatment was associated with higher incidences of prolonged SARS-CoV-2 infection (OR 27.05, 95% CI 3.75-195.22, p = 0.001) and severe COVID-19(OR 15.07, 95% CI 2.58-91.72, p = 0.003).
Conclusions: Our study suggested that patients treated with obinutuzumab had a higher risk of prolonged SARS-CoV-2 infection and severe COVID-19 than those treated with rituximab.
Keywords: COVID-19; Lymphoma; Obinutuzumab; Prolonged SARS-CoV-2 infection; Rituximab.