tetano
Editor, Senior Moderator
Virol Sin
. 2025 Apr 7:S1995-820X(25)00037-9.
doi: 10.1016/j.virs.2025.04.002. Online ahead of print. Comparative metatranscriptome analysis in gut reveals insignificant host or microbiota changes in SARS-related coronavirus naturally infected bats
Qi Wang[SUP] 1 [/SUP], Shi-Qiang Mei[SUP] 2 [/SUP], Tian-Yi Dong[SUP] 1 [/SUP], Jia Su[SUP] 1 [/SUP], Yuan-Fei Pan[SUP] 3 [/SUP], Yan Zhu[SUP] 1 [/SUP], Ke Wu[SUP] 1 [/SUP], Li-Biao Zhang[SUP] 4 [/SUP], Mang Shi[SUP] 5 [/SUP], Peng Zhou[SUP] 6 [/SUP]
Affiliations
It is believed that bats, a natural reservoir host of coronaviruses (CoVs), may coexist with virus for long-term without showing symptoms of diseases. However, this description is mainly from observation on wild-captured bats, but without molecular quantitative indicators. In human, SARS-CoV-2 infection causes dysregulated immune responses and microbiota populations, which predicts the progress of diseases. We hypothesize that the similar strategy may help to quantitatively describe the bat-virus interaction statement. Thus, we did metatranscriptome analysis to 50 SARS-related coronaviruses (SARSr-CoVs) naturally infected Rhinolophus sinicus bats, with 32 control samples from the same bat species. Using similar human intestinal data as comparison, we found SARS-CoV-2 infection caused significant host pro-inflammatory responses or microbiota population changes. In contrast, we found viruses (mainly SARSr-CoVs) is an insignificant variable factor to the bat host transcriptome or microbiota population among a series of factors tested. Notably, sampling environment contributed even more than viruses to the overall changes of metatranscriptome. Moreover, we also found the co-circulating virome was not changed following SARSr-CoVs infection. Thus, we conclude that viruses, mainly SARSr-CoVs do not change the homeostasis in the gut microenvironment in R. sinicus bats, which likely related to long-term coexistence between bats and viruses. Our work shed light on the understanding of how bats co-exist with viruses.
Keywords: Bats; Gut homeostasis; Host immunity; Microbiota; SARS-related coronavirus (SARSr-CoVs).
. 2025 Apr 7:S1995-820X(25)00037-9.
doi: 10.1016/j.virs.2025.04.002. Online ahead of print. Comparative metatranscriptome analysis in gut reveals insignificant host or microbiota changes in SARS-related coronavirus naturally infected bats
Qi Wang[SUP] 1 [/SUP], Shi-Qiang Mei[SUP] 2 [/SUP], Tian-Yi Dong[SUP] 1 [/SUP], Jia Su[SUP] 1 [/SUP], Yuan-Fei Pan[SUP] 3 [/SUP], Yan Zhu[SUP] 1 [/SUP], Ke Wu[SUP] 1 [/SUP], Li-Biao Zhang[SUP] 4 [/SUP], Mang Shi[SUP] 5 [/SUP], Peng Zhou[SUP] 6 [/SUP]
Affiliations
- PMID: 40204156
- DOI: 10.1016/j.virs.2025.04.002
It is believed that bats, a natural reservoir host of coronaviruses (CoVs), may coexist with virus for long-term without showing symptoms of diseases. However, this description is mainly from observation on wild-captured bats, but without molecular quantitative indicators. In human, SARS-CoV-2 infection causes dysregulated immune responses and microbiota populations, which predicts the progress of diseases. We hypothesize that the similar strategy may help to quantitatively describe the bat-virus interaction statement. Thus, we did metatranscriptome analysis to 50 SARS-related coronaviruses (SARSr-CoVs) naturally infected Rhinolophus sinicus bats, with 32 control samples from the same bat species. Using similar human intestinal data as comparison, we found SARS-CoV-2 infection caused significant host pro-inflammatory responses or microbiota population changes. In contrast, we found viruses (mainly SARSr-CoVs) is an insignificant variable factor to the bat host transcriptome or microbiota population among a series of factors tested. Notably, sampling environment contributed even more than viruses to the overall changes of metatranscriptome. Moreover, we also found the co-circulating virome was not changed following SARSr-CoVs infection. Thus, we conclude that viruses, mainly SARSr-CoVs do not change the homeostasis in the gut microenvironment in R. sinicus bats, which likely related to long-term coexistence between bats and viruses. Our work shed light on the understanding of how bats co-exist with viruses.
Keywords: Bats; Gut homeostasis; Host immunity; Microbiota; SARS-related coronavirus (SARSr-CoVs).