tetano
Editor, Senior Moderator
Arch Virol. 2018 Jan 24. doi: 10.1007/s00705-018-3730-0. [Epub ahead of print]
[h=1]Virological and pathological characterization of an avian H1N1 influenza A virus.[/h] Koo BS[SUP]1[/SUP], Kim HK[SUP]1[/SUP], Song D[SUP]2[/SUP], Na W[SUP]2[/SUP], Song MS[SUP]3[/SUP], Kwon JJ[SUP]3[/SUP], Wong SS[SUP]4[/SUP], Noh JY[SUP]1[/SUP], Ahn MJ[SUP]1,[/SUP][SUP]5[/SUP], Kim DJ[SUP]1[/SUP], Webby RJ[SUP]4[/SUP], Yoon SW[SUP]6,[/SUP][SUP]7[/SUP], Jeong DG[SUP]8,[/SUP][SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Gene segments from avian H1N1 influenza A viruses have reassorted with other influenza viruses to generate pandemic strains over the past century. Nevertheless, little effort has been invested in understanding the characteristics of avian H1N1 influenza viruses. Here, we present the genome sequence and a molecular and virological characterization of an avian influenza A virus, A/wild bird/Korea/SK14/2014 (A/SK14, H1N1), isolated from migratory birds in South Korea during the winter season of 2014-2015. Full-genome sequencing and phylogenetic analysis revealed that the virus belongs to the Eurasian avian lineage. Although it retained avian-receptor binding preference, A/SK14 virus also exhibited detectable human-like receptor binding and was able to replicate in differentiated primary normal human bronchial epithelial cells. In animal models, A/SK14 virus was moderately pathogenic in mice, and virus was detected in nasal washes from inoculated guinea pigs, but not in direct-contact guinea pigs. Although A/SK14 showed moderate pathogenicity and no evidence of transmission in a mammalian model, our results suggest that the dual receptor specificity of A/SK14-like virus might allow for a more rapid adaptation to mammals, emphasizing the importance of further continuous surveillance and risk-assessment activities.
PMID: 29368065 DOI: 10.1007/s00705-018-3730-0
[h=1]Virological and pathological characterization of an avian H1N1 influenza A virus.[/h] Koo BS[SUP]1[/SUP], Kim HK[SUP]1[/SUP], Song D[SUP]2[/SUP], Na W[SUP]2[/SUP], Song MS[SUP]3[/SUP], Kwon JJ[SUP]3[/SUP], Wong SS[SUP]4[/SUP], Noh JY[SUP]1[/SUP], Ahn MJ[SUP]1,[/SUP][SUP]5[/SUP], Kim DJ[SUP]1[/SUP], Webby RJ[SUP]4[/SUP], Yoon SW[SUP]6,[/SUP][SUP]7[/SUP], Jeong DG[SUP]8,[/SUP][SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Gene segments from avian H1N1 influenza A viruses have reassorted with other influenza viruses to generate pandemic strains over the past century. Nevertheless, little effort has been invested in understanding the characteristics of avian H1N1 influenza viruses. Here, we present the genome sequence and a molecular and virological characterization of an avian influenza A virus, A/wild bird/Korea/SK14/2014 (A/SK14, H1N1), isolated from migratory birds in South Korea during the winter season of 2014-2015. Full-genome sequencing and phylogenetic analysis revealed that the virus belongs to the Eurasian avian lineage. Although it retained avian-receptor binding preference, A/SK14 virus also exhibited detectable human-like receptor binding and was able to replicate in differentiated primary normal human bronchial epithelial cells. In animal models, A/SK14 virus was moderately pathogenic in mice, and virus was detected in nasal washes from inoculated guinea pigs, but not in direct-contact guinea pigs. Although A/SK14 showed moderate pathogenicity and no evidence of transmission in a mammalian model, our results suggest that the dual receptor specificity of A/SK14-like virus might allow for a more rapid adaptation to mammals, emphasizing the importance of further continuous surveillance and risk-assessment activities.
PMID: 29368065 DOI: 10.1007/s00705-018-3730-0