tetano
Editor, Senior Moderator
Virology
. 2024 Sep 5:600:110231.
doi: 10.1016/j.virol.2024.110231. Online ahead of print. Susceptibilities and viral shedding of peridomestic wildlife infected with clade 2.3.4.4b highly pathogenic avian influenza virus (H5N1)
J Jeffrey Root[SUP] 1 [/SUP], Stephanie M Porter[SUP] 2 [/SUP], Julianna B Lenoch[SUP] 3 [/SUP], Jeremy W Ellis[SUP] 2 [/SUP], Angela M Bosco-Lauth[SUP] 4 [/SUP]
Affiliations
We tested the ability of six peridomestic wildlife species to replicate a highly pathogenic (HP) clade 2.3.4.4b AIV (H5N1) isolated in the U.S. during 2022. All tested species replicated and shed virus, at least to some degree. Of the six species evaluated (house sparrows (Passer domesticus), European starlings (Sturnus vulgaris), feral pigeons (Columba livia), striped skunks (Mephitis mephitis), Virginia opossums (Didelphis virginiana), and cottontails (Sylvilagus sp.)), striped skunks and Virginia opossums shed the highest viral titers of 10[SUP]6.3[/SUP] PFU/mL and 10[SUP]5.0[/SUP] PFU/mL, respectively. Overall, the results of this study indicate that certain peridomestic species could pose a biosecurity threat to poultry operations in some situations. In addition, this study and field reports indicate that the HP AIVs circulating in the U.S. during 2022-2024 may have an extremely broad range of species that can be impacted by and/or replicate and shed these viruses.
Keywords: Avian influenza A virus; Biosecurity; Bird; Clade 2.3.4.4b; Experimental infection; Highly pathogenic H5N1; Mammal; Peridomestic wildlife.
. 2024 Sep 5:600:110231.
doi: 10.1016/j.virol.2024.110231. Online ahead of print. Susceptibilities and viral shedding of peridomestic wildlife infected with clade 2.3.4.4b highly pathogenic avian influenza virus (H5N1)
J Jeffrey Root[SUP] 1 [/SUP], Stephanie M Porter[SUP] 2 [/SUP], Julianna B Lenoch[SUP] 3 [/SUP], Jeremy W Ellis[SUP] 2 [/SUP], Angela M Bosco-Lauth[SUP] 4 [/SUP]
Affiliations
- PMID: 39278105
- DOI: 10.1016/j.virol.2024.110231
We tested the ability of six peridomestic wildlife species to replicate a highly pathogenic (HP) clade 2.3.4.4b AIV (H5N1) isolated in the U.S. during 2022. All tested species replicated and shed virus, at least to some degree. Of the six species evaluated (house sparrows (Passer domesticus), European starlings (Sturnus vulgaris), feral pigeons (Columba livia), striped skunks (Mephitis mephitis), Virginia opossums (Didelphis virginiana), and cottontails (Sylvilagus sp.)), striped skunks and Virginia opossums shed the highest viral titers of 10[SUP]6.3[/SUP] PFU/mL and 10[SUP]5.0[/SUP] PFU/mL, respectively. Overall, the results of this study indicate that certain peridomestic species could pose a biosecurity threat to poultry operations in some situations. In addition, this study and field reports indicate that the HP AIVs circulating in the U.S. during 2022-2024 may have an extremely broad range of species that can be impacted by and/or replicate and shed these viruses.
Keywords: Avian influenza A virus; Biosecurity; Bird; Clade 2.3.4.4b; Experimental infection; Highly pathogenic H5N1; Mammal; Peridomestic wildlife.