tetano
Editor, Senior Moderator
Viruses
. 2021 Dec 16;13(12):2526.
doi: 10.3390/v13122526.
First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain
Leira Fernández-Bastit[SUP] 1 [/SUP], Jordi Rodon[SUP] 1 [/SUP], Edwards Pradenas[SUP] 2 [/SUP], Silvia Marfil[SUP] 2 [/SUP], Benjamin Trinité[SUP] 2 [/SUP], Mariona Parera[SUP] 2 [/SUP], Núria Roca[SUP] 1 [/SUP], Anna Pou[SUP] 1 [/SUP], Guillermo Cantero[SUP] 1 [/SUP], Cristina Lorca-Oró[SUP] 1 [/SUP], Jorge Carrillo[SUP] 2 3 [/SUP], Nuria Izquierdo-Useros[SUP] 2 3 [/SUP], Bonaventura Clotet[SUP] 2 4 [/SUP], Marc Noguera-Julián[SUP] 2 4 [/SUP], Julià Blanco[SUP] 2 3 4 [/SUP], Júlia Vergara-Alert[SUP] 1 [/SUP], Joaquim Segalés[SUP] 5 6 [/SUP]
Affiliations
Abstract
Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we document the first reported case of infection caused by the Delta (B.1.617.2) variant of concern (VOC) in a dog in Spain that lived with several household members suffering from Coronavirus Infectious Disease 2019 (COVID-19). The animal displayed mild digestive and respiratory clinical signs and had a low viral load in the oropharyngeal swab collected at the first sampling. Whole-genome sequencing indicated infection with the Delta variant, coinciding with the predominant variant during the fifth pandemic wave in Spain. The dog seroconverted, as detected 21 days after the first sampling, and developed neutralizing antibodies that cross-neutralized different SARS-CoV-2 variants. This study further emphasizes the importance of studying the susceptibility of animal species to different VOCs and their potential role as reservoirs in the context of COVID-19.
Keywords: B.1.617.2; COVID-19; Delta variant; SARS-CoV-2; dog; pets; reverse zoonosis; transmission; variants of concern.
. 2021 Dec 16;13(12):2526.
doi: 10.3390/v13122526.
First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain
Leira Fernández-Bastit[SUP] 1 [/SUP], Jordi Rodon[SUP] 1 [/SUP], Edwards Pradenas[SUP] 2 [/SUP], Silvia Marfil[SUP] 2 [/SUP], Benjamin Trinité[SUP] 2 [/SUP], Mariona Parera[SUP] 2 [/SUP], Núria Roca[SUP] 1 [/SUP], Anna Pou[SUP] 1 [/SUP], Guillermo Cantero[SUP] 1 [/SUP], Cristina Lorca-Oró[SUP] 1 [/SUP], Jorge Carrillo[SUP] 2 3 [/SUP], Nuria Izquierdo-Useros[SUP] 2 3 [/SUP], Bonaventura Clotet[SUP] 2 4 [/SUP], Marc Noguera-Julián[SUP] 2 4 [/SUP], Julià Blanco[SUP] 2 3 4 [/SUP], Júlia Vergara-Alert[SUP] 1 [/SUP], Joaquim Segalés[SUP] 5 6 [/SUP]
Affiliations
- PMID: 34960795
- DOI: 10.3390/v13122526
Abstract
Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we document the first reported case of infection caused by the Delta (B.1.617.2) variant of concern (VOC) in a dog in Spain that lived with several household members suffering from Coronavirus Infectious Disease 2019 (COVID-19). The animal displayed mild digestive and respiratory clinical signs and had a low viral load in the oropharyngeal swab collected at the first sampling. Whole-genome sequencing indicated infection with the Delta variant, coinciding with the predominant variant during the fifth pandemic wave in Spain. The dog seroconverted, as detected 21 days after the first sampling, and developed neutralizing antibodies that cross-neutralized different SARS-CoV-2 variants. This study further emphasizes the importance of studying the susceptibility of animal species to different VOCs and their potential role as reservoirs in the context of COVID-19.
Keywords: B.1.617.2; COVID-19; Delta variant; SARS-CoV-2; dog; pets; reverse zoonosis; transmission; variants of concern.