• FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
  • We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.

What's on the genetic menu for New A/H1N1 and seasonal A/H1N1 & A/H3N2 swapping?

Re: What's on the genetic menu for New A/H1N1 and seasonal A/H1N1 & A/H3N2 swapping?

bump this since there is renewed interest in potential mutations.

.
 
Re: What's on the genetic menu for New A/H1N1 and seasonal A/H1N1 & A/H3N2 swapping?

bumping makes less sense now that I get too many new posts
in the morning to even read the headlines.

I think I'll have to restrict to certain subforums
or subscribe to threads.
 
Re: What's on the genetic menu for New A/H1N1 and seasonal A/H1N1 & A/H3N2 swapping?

Mamabird said:
Provided in 1, below are the problem amino acids associated with the currently circulating Swine Flu. These are generally found in every pandemic virus and most seasonal flu viruses, and some relate to sensitivity to antivirals, etc. All the available Swine Flu virus gene sequences have these human/problem characteristics.

1. PB2: A199S; PB1 N(T)375S; PB1-F2 P(R)48Q; PA T129I and S409N; HA E190D, S221P, F251L and Y258F; NP V33I, R100V and Q357K; MP K27R, I168T and N224S; M2 none; NS2 F55L; NA none.

Provided in 2, below are those amino acids that this bug has not yet obtained, but if obtained, could be problematic. Some are more important that others. None of the Swine Flu viruses have these characteristics as far as I know, but we should all keep an eye out for them>

2. PB2 L(F)475M, D567N and E627K; PB1 none; PB1-F2 P28L, D55N, I(V)100A and T552S; HA multi-basic amino acids at the clevage site (usually associated only with poultry infections); NP G16D, L283P and F313Y; MP I15V, K101R, A166V and N207S; M2 E16G and S20N; NS none; NS2 none; NA H274Y and N294S.

In other words, the Swine Flu virus has about half of the problem amino acids already in its tool box. The only other viruses even close to this are some H9N2 viruses circulating widely in Hong Kong and H7N7 in the Netherlands. As to the wild type avian viruses, only the North American variety come close.

Take away: This is a problem virus that bears watching closely. Reassortment with seasonal flu or H5N1 could be interesting.
Click to expand...

HA I219K should be associated with increased transmission by droplets
 
Re: What's on the genetic menu for New A/H1N1 and seasonal A/H1N1 & A/H3N2 swapping?

gsgs said:
bumping makes less sense now that I get too many new posts
in the morning to even read the headlines.

I think I'll have to restrict to certain subforums
or subscribe to threads.
Click to expand...

I agree, its getting harder and harder to keep up. Where we used to have a global discussion, it is getting more regional I guess due to time differences and volume of new posts.
 
You must log in or register to reply here.
Back
Top Bottom