tetano
Editor, Senior Moderator
World J Clin Cases
. 2023 Feb 6;11(4):756-763.
doi: 10.12998/wjcc.v11.i4.756.
Chest computed tomography findings of the Omicron variants of SARS-CoV-2 with different cycle threshold values
Wei-Feng Ying[SUP] 1 [/SUP], Qiong Chen[SUP] 2 [/SUP], Zhi-Kui Jiang[SUP] 3 [/SUP], Da-Guang Hao[SUP] 1 [/SUP], Ying Zhang[SUP] 1 [/SUP], Qian Han[SUP] 3 [/SUP]
Affiliations
Abstract
Background: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the upper respiratory tract. This study aimed to determine whether the probability of pulmonary infection and the cycle threshold (Ct) measured using the fluorescent polymerase chain reaction (PCR) method were related to pulmonary infections diagnosed via computed tomography (CT).
Aim: To analyze the chest CT signs of SARS-CoV-2 Omicron variant infections with different Ct values, as determined via PCR.
Methods: The chest CT images and PCR Ct values of 331 patients with SARS-CoV-2 Omicron variant infections were retrospectively collected and categorized into low (< 25), medium (25.00-34.99), and high (≥ 35) Ct groups. The characteristics of chest CT images in each group were statistically analyzed.
Results: The PCR Ct values ranged from 13.36 to 39.81, with 99 patients in the low, 155 in the medium, and 77 in the high Ct groups. Six abnormal chest CT signs were detected, namely, focal infection, patchy consolidation shadows, patchy ground-glass shadows, mixed consolidation ground-glass shadows, subpleural interstitial changes, and pleural changes. Focal infections were less frequent in the low Ct group than in the medium and high Ct groups; these infections were the most common sign in the medium and high Ct groups. Patchy consolidation shadows and pleural changes were more frequent in the low Ct group than in the other two groups. The number of patients with two or more signs was greater in the low Ct group than in the medium and high Ct groups.
Conclusion: The chest CT signs of patients with pulmonary infection caused by the Omicron variants of SARS-CoV-2 varied depending on the Ct values. Identification of the characteristics of Omicron variant infection can help subsequent planning of clinical treatment.
Keywords: COVID-19; Computed tomography; Cycle threshold; Omicron variant; Polymerase chain reaction; SARS-CoV-2.
. 2023 Feb 6;11(4):756-763.
doi: 10.12998/wjcc.v11.i4.756.
Chest computed tomography findings of the Omicron variants of SARS-CoV-2 with different cycle threshold values
Wei-Feng Ying[SUP] 1 [/SUP], Qiong Chen[SUP] 2 [/SUP], Zhi-Kui Jiang[SUP] 3 [/SUP], Da-Guang Hao[SUP] 1 [/SUP], Ying Zhang[SUP] 1 [/SUP], Qian Han[SUP] 3 [/SUP]
Affiliations
- PMID: 36818628
- PMCID: PMC9928689
- DOI: 10.12998/wjcc.v11.i4.756
Abstract
Background: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the upper respiratory tract. This study aimed to determine whether the probability of pulmonary infection and the cycle threshold (Ct) measured using the fluorescent polymerase chain reaction (PCR) method were related to pulmonary infections diagnosed via computed tomography (CT).
Aim: To analyze the chest CT signs of SARS-CoV-2 Omicron variant infections with different Ct values, as determined via PCR.
Methods: The chest CT images and PCR Ct values of 331 patients with SARS-CoV-2 Omicron variant infections were retrospectively collected and categorized into low (< 25), medium (25.00-34.99), and high (≥ 35) Ct groups. The characteristics of chest CT images in each group were statistically analyzed.
Results: The PCR Ct values ranged from 13.36 to 39.81, with 99 patients in the low, 155 in the medium, and 77 in the high Ct groups. Six abnormal chest CT signs were detected, namely, focal infection, patchy consolidation shadows, patchy ground-glass shadows, mixed consolidation ground-glass shadows, subpleural interstitial changes, and pleural changes. Focal infections were less frequent in the low Ct group than in the medium and high Ct groups; these infections were the most common sign in the medium and high Ct groups. Patchy consolidation shadows and pleural changes were more frequent in the low Ct group than in the other two groups. The number of patients with two or more signs was greater in the low Ct group than in the medium and high Ct groups.
Conclusion: The chest CT signs of patients with pulmonary infection caused by the Omicron variants of SARS-CoV-2 varied depending on the Ct values. Identification of the characteristics of Omicron variant infection can help subsequent planning of clinical treatment.
Keywords: COVID-19; Computed tomography; Cycle threshold; Omicron variant; Polymerase chain reaction; SARS-CoV-2.