tetano
Editor, Senior Moderator
World J Pediatr
. 2021 Jun 23.
doi: 10.1007/s12519-021-00431-2. Online ahead of print.
Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic
Yue-Yue Ding[SUP] #[/SUP][SUP] 1 [/SUP], Yan Ren[SUP] #[/SUP][SUP] 2 [/SUP], Jie Qin[SUP] #[/SUP][SUP] 1 [/SUP], Guang-Hui Qian[SUP] 3 [/SUP], Yun-Jia Tang[SUP] 1 [/SUP], Ye Chen[SUP] 1 [/SUP], Xuan Li[SUP] 1 [/SUP], Lei Xu[SUP] 1 [/SUP], Chun-Hong Qiao[SUP] 4 [/SUP], Ling Sun[SUP] 1 [/SUP], Hai-Tao Lv[SUP] 5 [/SUP]
Affiliations
Abstract
Background: The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods: All patients with KD admitted between February and April in 2015-2020, were classified into before (group 1, in 2015-2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (n = 98) and non-KD (n = 4644)] referred to Mycoplasma pneumoniae (MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results: Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion: Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.
Keywords: COVID-19; Concurrent pathogens; Isolation; Kawasaki disease; Mycoplasma pneumoniae.
. 2021 Jun 23.
doi: 10.1007/s12519-021-00431-2. Online ahead of print.
Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic
Yue-Yue Ding[SUP] #[/SUP][SUP] 1 [/SUP], Yan Ren[SUP] #[/SUP][SUP] 2 [/SUP], Jie Qin[SUP] #[/SUP][SUP] 1 [/SUP], Guang-Hui Qian[SUP] 3 [/SUP], Yun-Jia Tang[SUP] 1 [/SUP], Ye Chen[SUP] 1 [/SUP], Xuan Li[SUP] 1 [/SUP], Lei Xu[SUP] 1 [/SUP], Chun-Hong Qiao[SUP] 4 [/SUP], Ling Sun[SUP] 1 [/SUP], Hai-Tao Lv[SUP] 5 [/SUP]
Affiliations
- PMID: 34160770
- DOI: 10.1007/s12519-021-00431-2
Abstract
Background: The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods: All patients with KD admitted between February and April in 2015-2020, were classified into before (group 1, in 2015-2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (n = 98) and non-KD (n = 4644)] referred to Mycoplasma pneumoniae (MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results: Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion: Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.
Keywords: COVID-19; Concurrent pathogens; Isolation; Kawasaki disease; Mycoplasma pneumoniae.