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Previous posts on anti-bodies:
Presentation on the CR06-261 mAb, this presentation is on H5N1; apparently the same mab is effective against H1N1 (both seasonal and pandemic)
Crucell Receives NIH Award for the Development of Influenza Monoclonal Antibodies
Posted on : 2009-08-18 | Author : Crucell N.V.
News Category : PressRelease
LEIDEN, NETHERLANDS -- 08/18/09 --
Dutch biopharma company Crucell N.V. (Euronext, Nasdaq: CRXL; Swiss Exchange: CRX) today announced that it received a National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) contract aimed at advancing the development of monoclonal antibodies for the treatment of seasonal and pandemic influenza.
The contract provides funding of up to $40.7 million, with additional options that may be triggered at the discretion of the NIH worth a further $28.4 million, bringing the potential total amount to $69.1 million.
"With the world now at pandemic alert level six, and recent reports of A/H1N1 oseltamivir resistance occurring, the timing of this contract is extremely important" said Dr. Jaap Goudsmit, Crucell's Chief Scientific Officer. "It will allow Crucell and its partners to pursue a new approach for the treatment of the disease caused by both seasonal and pandemic influenza strains."
Crucell has developed a set of unique human monoclonal antibodies that have been shown to protect against a wide range of distinct seasonal and pandemic influenza viruses.
These antibodies are active against the seasonal H1N1 viruses, which show widespread resistance to oseltamivir (Tamiflu), the current first-line therapeutic. They were also found to be active against the pandemic 'swine flu' H1N1 influenza viruses and the avian H5N1 'bird flu' viruses, which are still circulating in Asia.
In December 2008, Crucell published pre-clinical data showing the prophylactic and therapeutic efficacy of these antibodies in the online journal PLoS ONE. This was followed in February 2009 by a breakthrough publication in the journal Science elucidating the mechanism of action of the most potent of these antibodies.
The NIH award confirms the validity of Crucell's innovative antibody approach, spearheaded by the rabies monoclonal program.
Crucell will be the primary contractor with additional services being supplied by Quintiles Guys Drug Research Unit and RetroScreen Ltd, both located in London, as well as Viroclinics and Central Veterinary Institute, both located in the Netherlands.
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About Influenza antibodies H1N1 and H5N1
Crucell has discovered the first human monoclonal antibodies for the prevention and treatment of the 'bird flu' strain H5N1, as well as H1N1, which is similar to the strain responsible for the 'Spanish flu' in 1918. The antibodies provide immediate protection and neutralize a broad range of H5N1 and H1N1 strains in pre-clinical models.
In December 2008, Crucell presented data showing that the mAb CR6261 was 100% successful in preventing infection with H5N1. When given after H5N1 infection, Crucell's mAb demonstrated the ability to prevent death and cure disease in all cases.
The mAb also performed significantly better than the anti-influenza drug oseltamivir for the prevention and treatment of H1N1 infection, illustrating the potential use for seasonal applications as well. This is especially important as the resistance of influenza strains for oseltamivir is rapidly increasing.
Presentation on the CR06-261 mAb, this presentation is on H5N1; apparently the same mab is effective against H1N1 (both seasonal and pandemic)
Crucell Receives NIH Award for the Development of Influenza Monoclonal Antibodies
Posted on : 2009-08-18 | Author : Crucell N.V.
News Category : PressRelease
LEIDEN, NETHERLANDS -- 08/18/09 --
Dutch biopharma company Crucell N.V. (Euronext, Nasdaq: CRXL; Swiss Exchange: CRX) today announced that it received a National Institute of Allergy and Infectious Diseases (NIAID)/National Institutes of Health (NIH) contract aimed at advancing the development of monoclonal antibodies for the treatment of seasonal and pandemic influenza.
The contract provides funding of up to $40.7 million, with additional options that may be triggered at the discretion of the NIH worth a further $28.4 million, bringing the potential total amount to $69.1 million.
"With the world now at pandemic alert level six, and recent reports of A/H1N1 oseltamivir resistance occurring, the timing of this contract is extremely important" said Dr. Jaap Goudsmit, Crucell's Chief Scientific Officer. "It will allow Crucell and its partners to pursue a new approach for the treatment of the disease caused by both seasonal and pandemic influenza strains."
Crucell has developed a set of unique human monoclonal antibodies that have been shown to protect against a wide range of distinct seasonal and pandemic influenza viruses.
These antibodies are active against the seasonal H1N1 viruses, which show widespread resistance to oseltamivir (Tamiflu), the current first-line therapeutic. They were also found to be active against the pandemic 'swine flu' H1N1 influenza viruses and the avian H5N1 'bird flu' viruses, which are still circulating in Asia.
In December 2008, Crucell published pre-clinical data showing the prophylactic and therapeutic efficacy of these antibodies in the online journal PLoS ONE. This was followed in February 2009 by a breakthrough publication in the journal Science elucidating the mechanism of action of the most potent of these antibodies.
The NIH award confirms the validity of Crucell's innovative antibody approach, spearheaded by the rabies monoclonal program.
Crucell will be the primary contractor with additional services being supplied by Quintiles Guys Drug Research Unit and RetroScreen Ltd, both located in London, as well as Viroclinics and Central Veterinary Institute, both located in the Netherlands.
- snip -
About Influenza antibodies H1N1 and H5N1
Crucell has discovered the first human monoclonal antibodies for the prevention and treatment of the 'bird flu' strain H5N1, as well as H1N1, which is similar to the strain responsible for the 'Spanish flu' in 1918. The antibodies provide immediate protection and neutralize a broad range of H5N1 and H1N1 strains in pre-clinical models.
In December 2008, Crucell presented data showing that the mAb CR6261 was 100% successful in preventing infection with H5N1. When given after H5N1 infection, Crucell's mAb demonstrated the ability to prevent death and cure disease in all cases.
The mAb also performed significantly better than the anti-influenza drug oseltamivir for the prevention and treatment of H1N1 infection, illustrating the potential use for seasonal applications as well. This is especially important as the resistance of influenza strains for oseltamivir is rapidly increasing.
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