China: Human H5N1 Cases for 2009

[Laidback Al]

Re: China - Guangxi region, Man, 18 Dies from H5N1

The 18-year-old was admitted to hospital on Jan 24 in Yulin, in the southwestern Guangxi, bordering Vietnam, after falling ill and entering a local clinic in the town of Beiliu three days earlier.

Originally infected in Beiliu Guangxi, China (also known as Lingcheng, Pei-liu-hsien, Paklow, Pei-liu, Paklow-hsien, Pie-liu, Beiliu) 22.7072, 110.3492
Hospitalized in 北流市, Yulin, Guangxi, China (also Yü-lin-chen, Watlam-hsien, Yü-lin-hsien,Yo-ling, Yu-lin-chen, Watlam, Yu-lin-hsien) 22.516759, 110. 482356

[HenryN]

Re: China - Guangxi region, Man, 18 Dies from H5N1

Originally infected in Beiliu Guangxi, China (also known as Lingcheng, Pei-liu-hsien, Paklow, Pei-liu, Paklow-hsien, Pie-liu, Beiliu) 22.7072, 110.3492
Hospitalized in 北流市, Yulin, Guangxi, China (also Y?-lin-chen, Watlam-hsien, Y?-lin-hsien,Yo-ling, Yu-lin-chen, Watlam, Yu-lin-hsien) 22.516759, 110. 482356

Updated map

http://maps.google.com/maps/ms?ie=UTF8&hl=en&msa=0&t=h&msid=106484775090296685271.00045fcd12b84ad3ac0d8&ll=22.522071,110.482335&spn=8.964238,13.491211&z=6&iwloc=00046165e311da68bbf0e

[AlaskaDenise]

Re: China - Guangxi region, Man, 18 Dies from H5N1

Commentary

http://www.recombinomics.com/News/01..._Concerns.html

Commentary

Concerns of Increased H5N1 Transmission Efficiency in China
Recombinomics Commentary 14:55
January 26, 2009


The latest series of confirmed H5N1 cases in China indicate the H5N1 has achieved more efficient transmission to humans. Two of the cases are linked to contacts who had bird flu symptoms. In Beijing, a nurse recovered and test results have not been released. In Hunan, the mother of the confirmed case (2F) died of pneumonia when the daughter developed symptoms. Thus, in both clusters the index case died, but the contact survived. This was also reported in the cluster in northern Vietnam. The index case (13F) died of pneumonia, which her sister (8F) and neighbor (5M) survived. The survival of these cluster members is consistent with human to human transmission, which involves a low viral load, leading to milder cases.

Milder cases in China and Vietnam (see updated map) remain a concern. In China, all seven recent confirmed cases were admitted in critical condition. One is recovering, one is stable, and the other five are dead. This high case fatality rate suggests milder cases are not being detected / reported.

On the reporting front, the only H5N1 in poultry has been two outbreaks in Jiangsu in asymptomatic birds. Although some of the recent human cases have been linked to poultry exposure, there has been an absence of linkages to dead, dying, or H5N1 confirmed poultry.

This lack of poultry links raises concerns that the poultry is asymptomatically infected, which can be due to a vaccine mismatch. The outbreak in Jiangsu was due to clade 7, which is not well matched to clade 1 or clade 2 vaccines. The outbreak in Jiangsu was followed by new vaccinations of unaffected flocks. This pattern is similar to the series of outbreaks in northern China in the 2005/2006.These poultry outbreaks were not well controlled, and at least some of these outbreaks also involved clade 7, which has been detected in northern China, as well as Hunan. Moreover, it was recently detected in northern Vietnam and an isolate from Vietnam was recently selected as a human vaccine target, although no human vaccine against clade 7 is currently available.

Media reports in China have indicated A/Beijing/1/2009 was similar to H5N1 circulating in China between 2005-2008. This would be consistent with clade 7, which was widely detected in 2005. However, it also caused the first confirmed case in China, which was in Beijing in 2003. Moreover, clade 2.3.4 has been linked to most reported H5N1 human cases in China and it also has been widely circulating between 2005-2008 and also has origins dating back to 2003, so the description of A/Beijing/1/2009 is ambiguous with regard to clade number.

Clade 7 has a large number of receptor binding domain changes flanking position 190, which is also true for the Tamiflu resistant H1N1 seasonal flu, which has spread throughout the northern hemisphere.

The co-circulation of clade 7 H5N1 and clade 2B H1N1 which has H274Y is an additional cause for concern, with regard to Tamiflu resistance on N and exchanges of receptor binding domain changes on H.

More information on the H5N1 clade linked to human cases in China and Vietnam would be useful as would release of H5N1 sequences from the recent cases in both countries.

.

[AlaskaDenise]

Re: China - Guangxi region, Man, 18 Dies from H5N1

Regarding the statements about H2H recovery, low viral loads, & milder cases: Is this an indicator of what we can expect if/when BF becomes efficiently H2H? In the past, I believe someone said that a new virus is milder due to the "experienced" genetics it picks up via reassortment, but can that be true for a different reason when a virus adapts via recombination?

Given the increasing "similarities" in the HA, does this facilitate development of H2H capability by more than just acquisition of one polymorphism, i.e., will the speed of H2H development increase? What are some historic cases of increasing similarity preceeding large H2H-type changes, excluding reassortment? This may have been discussed in the past, but a review in the light of new examples might be enlightening.

.

[sharon sanders]

Re: China - Human H5N1 Cases January 29, 2009+ incl. Guangxi region, Man, 18 Dies from H5N1

hat tip Treyfish -

1月26日，广西确诊一例人感染高致病性禽流感病例。

January 26, Guangxi confirmed case of human infection of highly pathogenic avian influenza cases.

患者梁某，男，18岁，现住广西北流市。

Patients梁某, M, 18 years old, and currently residing in the city of广西北流.

患者2009年1月19日发病，即日前往当地卫生院就诊，后于1月24日转入广西玉林市红十字 会医院。

Patients January 19, 2009 incidence, the same day went to local hospitals for treatment, after January 24 transferred to Guangxi Yulin City, Red Cross Hospital.

因患者病情危重，经全力救治无效于1月26日死亡。

By patients in a critical condition, after the full treatment invalid in death January 26. http://66.102.1.101/translate_c?hl=e...vNJOJGDU5DzCmg

[sharon sanders]

Re: China - Guangxi Region, man, 18, Dies of Bird Flu

Thanks everyone!

Please post all new human cases to this thread unless there is already a thread dedicated to the victim. Please see below for the list.

Link to other recent Confirmed China bird flu cases:


Guizhou Province: Male 29 - Stable Condition

http://www.flutrackers.com/forum/showthread.php?t=92343

Hunan Province: Girl 2 - Stable Condition (possible cluster??)

http://www.flutrackers.com/forum/showthread.php?t=91522

Xinjiang, Province: woman, 31 - Death

http://www.flutrackers.com/forum/showthread.php?t=92223


Shandong Province: woman 27 - Death

http://www.flutrackers.com/forum/showthread.php?t=91617

Guizhou Province: Boy 16 - Death
http://www.flutrackers.com/forum/showthread.php?t=91723



Bejing: Woman 19 - Death

http://www.flutrackers.com/forum/showthread.php?t=90425

Map of Recent Cases:

http://www.flutrackers.com/forum/showpost.php?p=204782&postcount=5

[HenryN]

Re: China - Human H5N1 Cases January 29, 2009+ incl. Guangxi region, Man, 18 Dies from H5N1

<TABLE class=lan18 cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD class=hei22 vAlign=bottom height=25>Human infection of bird flu reported in central China
</TD></TR><TR><TD bgColor=#ffffff height=4></TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="50%" align=center border=0><TBODY><TR><TD height=8></TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD width="48%">www.chinaview.cn 2009-01-31 20:05:39</TD><TD class=hui12 align=middle width="26%"> </TD><TD class=hui12 align=middle width="12%"> Print</TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="80%" border=0><TBODY><TR><TD height=20></TD></TR></TBODY></TABLE><TABLE class=lt14 cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD class=lt14>


BEIJING, Jan. 31 (Xinhua) -- A 21-year-old female farmer was confirmed as infected with bird flu in central China's Hunan Province, said the provincial health authority on Saturday.
The patient was found sick on Jan. 23 and hospitalized on Jan. 26. So far she has been in stable condition and recovering.

http://news.xinhuanet.com/english/2009-01/31/content_10741532.htm

</TD></TR></TBODY></TABLE>

[HenryN]

Re: China - Human H5N1 Cases January 29, 2009+ incl. Guangxi region, Man, 18 Dies from H5N1

http://www.moh.gov.cn/publicfiles/business/htmlfiles/wsb/pyqxx/200901/38933.htm

Infection Hunan confirmed case of human cases of highly pathogenic avian influenza


Hunan Provincial Department of Health January 31 briefing, the province confirmed case of human infection of highly pathogenic avian influenza cases.

舒某某patients, female, 21 years old, farmers, who lives in Hunan Province溆浦县. Patients January 23, 2009 in the incidence溆浦县whose condition had worsened in the January 26 People's Hospital溆浦县treatment, January 29 transferred to Changsha Xiangya Hospital, Central South University hospital. At present, the basic stability of patients, clinical symptoms improved significantly and are actively in treatment.

January 29, Hunan Province Center for Disease Control and Prevention laboratory specimens of patients with detection, the results for the H5 subtype avian influenza virus nucleic acid positive; January 30, the Chinese Center for Disease Control and Prevention to conduct a review of patient specimen testing, the results for the birds H5N1 influenza virus nucleic acid positive. Epidemiological survey found that patients had come into contact with dead poultry.

According to World Health Organization of human infection with highly pathogenic avian influenza confirmed case definition and diagnostic criteria in China, Hunan Provincial Department of Health of human infection with highly pathogenic avian influenza prevention and control of the expert group to determine the cases of human infection of highly pathogenic avian influenza confirmed cases.

After the outbreak, the local government attaches great importance to have been in accordance with the "human infection with highly pathogenic avian influenza contingency plans" to take the corresponding control measures. All close contacts of the implementation of strict medical observation, and timely to conduct a comprehensive epidemiological investigation. Up to now, all close contacts are not unusual clinical manifestations.

The cases of the situation, the Ministry of Health has been the World Health Organization, Hong Kong, Macao and Taiwan regions and relevant national communications.

[HenryN]

Re: China - Human H5N1 Cases January 29, 2009+ incl. Guangxi region, Man, 18 Dies from H5N1

Updated map

http://maps.google.com/maps/ms?ie=UTF8&hl=en&msa=0&t=p&msid=106484775090296685271.00045fcd12b84ad3ac0d8&ll=31.690782,117.070313&spn=17.862365,25.488281&z=5

[Treyfish]

Re: China - Human H5N1 Cases January 29+

Hunan 21 year old of female agriculture dyes the bird flu Hong Kong to attain the notification
2009-01-31 19:56

[on.cc special news]The department of health health protection center receives the National Medical department to notify human exposure bird flu H5N1 today the diagnosis case. The patient is 21 year-old farmers, resides in the Hunan Province Xupu County, is taken bad in the 23rd of the month, right now accepts the treatment, the situation is stable, before she was taken bad, once contacted dies of illness the birds and beasts. Chinese Center for Disease Control and Prevention carries on the examination to the patient sample, the checking sample assumes the positive reaction to the bird flu H5N1 virus. The health protection center expressed that will continue with the National Medical department will maintain close contacting, understands the case the details. Since this has been 09 years the inland 8th ancestor dyes the bird flu case, 4 person of incurable.
http://66.196.80.202/babelfish/trans...3fid%3d8294476

[Treyfish]

Re: China - Human H5N1 Cases January 29+

Hunan溆浦县diagnosed a woman infected with highly pathogenic avian influenza

http://news.QQ.com 2009年01月31日20:17 新华网 我要评论( 0 )

http://news.QQ.com 2009 on 31 day 01 years 20:17 Xinhuanet I would like to comment (0)

新华网长沙1月31日电（记者周青梅）湖南省卫生厅31日通报，湖南省新确诊一例人感染高致病性禽流感病例 。

Changsha, China January 31 (Xinhua Qingmei) Hunan Provincial Department of Health briefing on the 31st, Hunan new confirmed case of human infection of highly pathogenic avian influenza cases.某某patients, female, 21 years old, farmers, who lives in Hunan Province溆浦县.

2009年1月23日在溆浦县发病，因病情加重，于1月26日到溆浦县人民医院住院治疗，1月29日转入位 于长沙市的中南大学湘雅医院住院治疗。

January 23, 2009 in the incidence溆浦县whose condition worsened on January 26 to溆浦县People's Hospital in-patient treatment into the January 29 is located in the city of Changsha, Central South University Xiangya Hospital hospitalization.

目前，患者病情基本稳定，临床症状明显

At present, the basic stability of patients, clinical symptoms

Improved medical staff are actively in treatment.
January 29, Hunan Province Center for Disease Control and Prevention laboratory specimens of patients with detection, the results for the H5 subtype avian influenza virus nucleic acid positive; January 30, the Chinese Center for Disease Control and Prevention to conduct a review of patient specimen testing, the results for the birds H5N1 influenza virus nucleic acid positive. Epidemiological survey found that patients had come into contact with dead poultry.
According to World Health Organization of human infection with highly pathogenic avian influenza confirmed case definition and diagnostic criteria of China, Hunan Provincial Department of Health of human infection with highly pathogenic avian influenza prevention and control of the expert group to determine the cases of human infection of highly pathogenic avian influenza confirmed cases.
After the outbreak, Hunan local government attaches great importance to have been in accordance with the "human infection with highly pathogenic avian influenza contingency plans" to take the corresponding control measures. At the same time, all close contacts to implement strict medical observation, and timely to conduct a comprehensive epidemiological investigation. Up to now, all close contacts are not unusual clinical manifestations.

。

The cases of the situation, the Ministry of Health has been the World Health Organization, Hong Kong, Macao and Taiwan regions and relevant national communications.
According to the Hunan Provincial Health Department briefing, January 19, Huaihua City, Hunan Province Guizhou confirmed case of human infection from highly pathogenic avian influenza patients, January 20, the patient died due to treatment.http://66.102.1.100/translate_c?hl=e...OtJnP84HmKXtBg

[Treyfish]

Re: China - Human H5N1 Cases January 29+

Hunan has a female to dye the bird flu again
2009-01-31 <!--START:NEWSTIME-->20:03: 00 <!--END:NEWSTIME-->
<!--START:PAGE_NEWS--><SCRIPT language=javascript src="/js/tooltip/wz_tooltip.js"></SCRIPT>
The National Medical department notifies, a Hunan female infects the H5N1 bird flu, this was this province recently the second case.

Patient Mr./Ms. Shu (21 years old) are a farmer, the family live in the Hunan Province 嵼 county. Patient on January 23 in 嵼 county morbidity, because the condition aggravates, on January 26 to 嵼 the County people's hospital hospital treatment, on 29th changes over to Changsha South central University Xiangya Hospital hospital treatment. At present, patient condition basic stable, clinical symptom obvious change for the better, is being treated and cured positively.

The epidemiology investigation discovery, before the patient was taken bad, once contacted has died of illness the domesticated fowl.

This case's related situation, Ministry of Health already to the World Health Organization, Hong Kong, Macao and Taiwan area and related national notification.
http://babelfish.yahoo.com/translate...n&btnTrUrl=Tra

[Shiloh]

Re: China - Human H5N1 Cases January 29+

Source: http://in.reuters.com/article/worldN...37763120090131

China woman infected by bird flu, recovering
Sat Jan 31, 2009 7:18pm IST

SHANGHAI (Reuters) - A 21-year-old woman has caught the H5N1 strain of bird flu in central China's Hunan Province but is recovering in hospital, the official Xinhua news agency said on Saturday.

The farmer was found sick on Jan. 23 after coming into contact with birds that died of the disease, Xinhua quoted provincial health authorities as saying.

People who had close contact with the patient are under observation, but none of them has fallen ill so far. China has reported the case to the World Health Organization, Xinhua added.

On Monday, China said a young man had died of the H5N1 strain of bird flu in the southwestern region of Guangxi, the country's fifth reported death from the disease this month.

H5N1 remains largely a virus among birds, but experts fear it could mutate into a form that is easily transmitted by humans, which could kill millions of people worldwide.

Since the virus resurfaced in Asia in 2003 it has infected about 400 people worldwide and killed over 250 of them, according to WHO data released earlier this month.

[HenryN]

Re: China - Human H5N1 Cases January 29+

Commentary

http://www.recombinomics.com/News/01310901/H5N1_Hunan_Again.html

[Rwilmer]

Re: China - Human H5N1 Cases January 29+

After this new case this definently makes me beleive that cases were way undereported in previous years.