I plan to add 5,000 units of Vitamin D to my daily regimen. There are a few people that should NOT take vitamin D. Those suffering from Hyperparathyroidism, which is a common cause of hypercalcemia. A simple blood test should be done to determine if you have this problem. Also those suffering from renal stones, sarcoidosis should not take additional Vitamin D. The rest of us need to make sure we have our vitamin D tanks on full during the months when sun exposure is insufficient to keep the D at healthy levels.
post #275
post #275
IMO, the Marshall Thesis while intriguing and using the modern language of science, is without scientific merit. There is no evidence to suggest the linchpin of his thesis is true; mainly that many human cell lines are infected with a large number of bacteria. There can be no ligands produced by intracellular bacteria that do not exist. These non-existent ligands then can not bind the VDR down regulating its function. For these reasons I reject the Marshall Thesis and also declare that his recommendation against the use of vitamin D supplements is misguided and if followed could be of harm especially among those who already have insufficient levels of serum 25 OH vit D.
What is an indisputable fact is vitamin D deficiency is highly prevalent in all human societies. The VDR is the target of vitamin D and regulates many processes within the human body that affect our health and susceptibility for disease. There have been an explosion of data on both the action of vitamin D, the VDR, and common human diseases that result due to vitamin D deficiency.
I resolve then that vitamin D deficiency is the cause of VDR dysfunction in most people with the exception of the small percentage of people with VDR polymorphisms which result in the VDR being variously resistant to the effects of vitamin D. What's more, replacement of vitamin D by the judicious use of sunlight and supplements is a vastly underutilized method of improving human health. The daily dose of vitamin D3 required to obtain the benefits of this hormone is at least 12 times higher than the RDA of 400iu. This level of intake equates to a dose of 5,000iu of vitamin D3 per day from all sources including sun exposure and supplements.
The jury remains out on the benefits and risks of vitamin D supplementation at the 5,000iu dose level but IMO the data is clear; supplementation is clearly warranted and very likely to substantially improve the health of those who follow this course.
At the conclusion of a debate, a time honored practice is to ask those who have participated in it to voice their opinion on what they learned for the exercise, what position they support as a result of it and in what way if any the information they gleaned as a result of the debate has affected their life choices and behavior.
I will go first. The vitamin D problem is real and supplementation is a very good answer to it. Using vitamin D3 is the best supplement to use and the lowest dose for optimal health is 5,000iu per day. Serum levels of 25 OH vit D3 is the best way to monitor body stores of vitamin D. Levels below 32ng/ml are inadequate for bone health and those below 50ng/ml are inadequate for immune health. The healthy and safe range for serum 25 OH vit D3 levels are between 50ng/ml and 80ng/ml. There is no benefit for having levels above 80ng/ml. Toxicity due to vitamin D3 is observed in those with serum 25 OH D3 levels above 120ng/ml; a level seen only in those who supplement with doses above 30,000iu of D3 daily (from all sources) and only after 2 months at this dose. Vitamin D supplementation is not safe or effective for everyone. These include people with and unexplained high blood calcium level, a history of kidney stones, a history of sarcoidosis, those with untreated primary hyperparathyroidism and for those with renal insufficiency.
The dose of vitamin D3 for children that is safe has not been studied enough but is probably no more than half the level for adults.
I look forward to hearing from both those who have participated in this debate on this thread as well as the large number of FT members who have simply observed it. I hope you all have enjoyed it as much as I have and wish to thank The Mountain's Voice for starting this thread. It has been very informative for me.
Grattan Woodson, MD
__________________
The Doctor
What is an indisputable fact is vitamin D deficiency is highly prevalent in all human societies. The VDR is the target of vitamin D and regulates many processes within the human body that affect our health and susceptibility for disease. There have been an explosion of data on both the action of vitamin D, the VDR, and common human diseases that result due to vitamin D deficiency.
I resolve then that vitamin D deficiency is the cause of VDR dysfunction in most people with the exception of the small percentage of people with VDR polymorphisms which result in the VDR being variously resistant to the effects of vitamin D. What's more, replacement of vitamin D by the judicious use of sunlight and supplements is a vastly underutilized method of improving human health. The daily dose of vitamin D3 required to obtain the benefits of this hormone is at least 12 times higher than the RDA of 400iu. This level of intake equates to a dose of 5,000iu of vitamin D3 per day from all sources including sun exposure and supplements.
The jury remains out on the benefits and risks of vitamin D supplementation at the 5,000iu dose level but IMO the data is clear; supplementation is clearly warranted and very likely to substantially improve the health of those who follow this course.
At the conclusion of a debate, a time honored practice is to ask those who have participated in it to voice their opinion on what they learned for the exercise, what position they support as a result of it and in what way if any the information they gleaned as a result of the debate has affected their life choices and behavior.
I will go first. The vitamin D problem is real and supplementation is a very good answer to it. Using vitamin D3 is the best supplement to use and the lowest dose for optimal health is 5,000iu per day. Serum levels of 25 OH vit D3 is the best way to monitor body stores of vitamin D. Levels below 32ng/ml are inadequate for bone health and those below 50ng/ml are inadequate for immune health. The healthy and safe range for serum 25 OH vit D3 levels are between 50ng/ml and 80ng/ml. There is no benefit for having levels above 80ng/ml. Toxicity due to vitamin D3 is observed in those with serum 25 OH D3 levels above 120ng/ml; a level seen only in those who supplement with doses above 30,000iu of D3 daily (from all sources) and only after 2 months at this dose. Vitamin D supplementation is not safe or effective for everyone. These include people with and unexplained high blood calcium level, a history of kidney stones, a history of sarcoidosis, those with untreated primary hyperparathyroidism and for those with renal insufficiency.
The dose of vitamin D3 for children that is safe has not been studied enough but is probably no more than half the level for adults.
I look forward to hearing from both those who have participated in this debate on this thread as well as the large number of FT members who have simply observed it. I hope you all have enjoyed it as much as I have and wish to thank The Mountain's Voice for starting this thread. It has been very informative for me.
Grattan Woodson, MD
__________________
The Doctor
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