sharon sanders
Editor-in-Chief & President
ORIGINAL RESEARCH article
Front. Oncol., 06 March 2024
Sec. Breast Cancer
Volume 14 - 2024 | https://doi.org/10.3389/fonc.2024.1346312
This article is part of the Research TopicWomen in Breast Cancer Vol III: 2023View all 16 articles
Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression
Hoai-Nga Thi Nguyen[SUP]1[/SUP]Cat-Khanh Vuong[SUP]1[/SUP]Mizuho Fukushige[SUP]1[/SUP]Momoko Usuda[SUP]1[/SUP]Liora Kaho Takagi[SUP]1[/SUP]Toshiharu Yamashita[SUP]1[/SUP]
Mana Obata-Yasuoka[SUP]2[/SUP]Hiromi Hamada[SUP]2[/SUP]
Motoo Osaka[SUP]3[/SUP]
Toru Tsukada[SUP]3[/SUP]
Yuji Hiramatsu[SUP]3[/SUP]Osamu Ohneda[SUP]1*[/SUP]
Methods: In the present study, the effects of M-protein on the ability of extracellular vesicles (EV) derived from triple-negative BCC to regulate the functions of tissue stem cells facilitating the tumor microenvironment were examined.
Results: Our results showed that EV derived from M-protein-induced triple-negative BCC (MpEV) significantly induced the paracrine effects of adipose tissue-derived mesenchymal stem cells (ATMSC) on non-aggressive BCC, promoting the migration, stemness phenotypes, and in vivo metastasis of BCC, which is related to PGE2/IL1 signaling pathways, in comparison to EV derived from normal triple-negative BCC (nEV). In addition to ATMSC, the effects of MpEV on endothelial progenitor cells (EPC), another type of tissue stem cells, were examined. Our data suggested that EPC uptaking MpEV acquired a tumor endothelial cell-like phenotype, with increasing angiogenesis and the ability to support the aggressiveness and metastasis of non-aggressive BCC.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1346312/full
Front. Oncol., 06 March 2024
Sec. Breast Cancer
Volume 14 - 2024 | https://doi.org/10.3389/fonc.2024.1346312
This article is part of the Research TopicWomen in Breast Cancer Vol III: 2023View all 16 articles
Extracellular vesicles derived from SARS-CoV-2 M-protein-induced triple negative breast cancer cells promoted the ability of tissue stem cells supporting cancer progression
Hoai-Nga Thi Nguyen[SUP]1[/SUP]Cat-Khanh Vuong[SUP]1[/SUP]Mizuho Fukushige[SUP]1[/SUP]Momoko Usuda[SUP]1[/SUP]Liora Kaho Takagi[SUP]1[/SUP]Toshiharu Yamashita[SUP]1[/SUP]
Hiromi Hamada[SUP]2[/SUP]
Osamu Ohneda[SUP]1*[/SUP]- [SUP]1[/SUP]Laboratory of Regenerative Medicine and Stem Cell Biology, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
- [SUP]2[/SUP]Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, Japan
- [SUP]3[/SUP]Department of Cardiovascular Surgery, University of Tsukuba, Tsukuba, Japan
Methods: In the present study, the effects of M-protein on the ability of extracellular vesicles (EV) derived from triple-negative BCC to regulate the functions of tissue stem cells facilitating the tumor microenvironment were examined.
Results: Our results showed that EV derived from M-protein-induced triple-negative BCC (MpEV) significantly induced the paracrine effects of adipose tissue-derived mesenchymal stem cells (ATMSC) on non-aggressive BCC, promoting the migration, stemness phenotypes, and in vivo metastasis of BCC, which is related to PGE2/IL1 signaling pathways, in comparison to EV derived from normal triple-negative BCC (nEV). In addition to ATMSC, the effects of MpEV on endothelial progenitor cells (EPC), another type of tissue stem cells, were examined. Our data suggested that EPC uptaking MpEV acquired a tumor endothelial cell-like phenotype, with increasing angiogenesis and the ability to support the aggressiveness and metastasis of non-aggressive BCC.
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1346312/full
