tetano
Editor, Senior Moderator
Environ Res. 2016 Nov 21;153:27-34. doi: 10.1016/j.envres.2016.11.004. [Epub ahead of print]
[h=1]2,3,7,8-tetrachlorodibenzo-p-dioxin and the viral infection.[/h] Fiorito F[SUP]1[/SUP], Santamaria R[SUP]2[/SUP], Irace C[SUP]2[/SUP], De Martino L[SUP]3[/SUP], Iovane G[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. In particular, several studies have provided evidence that TCDD decreases resistance to numerous viruses. Indeed, in vivo and in vitro investigations showed that the presence of TCDD is able to interfere with the replication of both human and animal viruses, such as influenza A viruses, coxsackie virus B3, immunodeficiency virus type-1 (HIV-1), cytomegalovirus (CMV), herpes simplex II, and bovine herpesvirus 1. Moreover, TCDD could induce an exacerbation of latent infection produced by HIV-1, CMV or Epstein-Barr virus. In this review, we first describe the general effects of TCDD exposure on mammalian cells, then we focus on its influence on the viral infections. Overall, the available data support the concept that TCDD exposure may act as an additional risk factor in promoting of viral diseases.
Copyright © 2016 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] AhR; TCDD; Viruses
PMID: 27883971 DOI: 10.1016/j.envres.2016.11.004
[PubMed - as supplied by publisher]
[h=1]2,3,7,8-tetrachlorodibenzo-p-dioxin and the viral infection.[/h] Fiorito F[SUP]1[/SUP], Santamaria R[SUP]2[/SUP], Irace C[SUP]2[/SUP], De Martino L[SUP]3[/SUP], Iovane G[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. In particular, several studies have provided evidence that TCDD decreases resistance to numerous viruses. Indeed, in vivo and in vitro investigations showed that the presence of TCDD is able to interfere with the replication of both human and animal viruses, such as influenza A viruses, coxsackie virus B3, immunodeficiency virus type-1 (HIV-1), cytomegalovirus (CMV), herpes simplex II, and bovine herpesvirus 1. Moreover, TCDD could induce an exacerbation of latent infection produced by HIV-1, CMV or Epstein-Barr virus. In this review, we first describe the general effects of TCDD exposure on mammalian cells, then we focus on its influence on the viral infections. Overall, the available data support the concept that TCDD exposure may act as an additional risk factor in promoting of viral diseases.
Copyright © 2016 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] AhR; TCDD; Viruses
PMID: 27883971 DOI: 10.1016/j.envres.2016.11.004
[PubMed - as supplied by publisher]