Emily
Editor, Senior Moderator
A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States
https://www.sciencedirect.com/science/article/pii/S0264410X21012950
George Lazaros, Cleo Anastassopoulou, Sophia Hatziantoniou, Theodoros Kalos, Stergios Soulaidopoulos, Emilia Lazarou, Charalambos Vlachopoulos, Dimitrios Vassilopoulos, Athanasios Tsakris, Costas Tsioufis,
A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States,
Vaccine,
Volume 39, Issue 45,
2021,
Pages 6585-6590,
ISSN 0264-410X,
https://doi.org/10.1016/j.vaccine.2021.09.078.
(https://www.sciencedirect.com/science/article/pii/S0264410X21012950)
Abstract: Background
COVID-19 vaccines were efficacious and safe in clinical trials. We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9).
Methods
All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines.
Findings
Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without sequelae; two events were complicated by cardiac tamponade requiring emergent pericardial decompression. Hospitalization was required in four cases.
Interpretation
Although causality cannot be firmly established, AP has emerged as a possible complication following COVID-19 vaccination. Further investigation is indispensable to fully characterize this new entity.
Keywords: COVID-19 vaccination; Pericarditis; mRNA vaccines; Adenovirus vector-based vaccines; SARS-CoV-2, outcome
https://www.sciencedirect.com/science/article/pii/S0264410X21012950
George Lazaros, Cleo Anastassopoulou, Sophia Hatziantoniou, Theodoros Kalos, Stergios Soulaidopoulos, Emilia Lazarou, Charalambos Vlachopoulos, Dimitrios Vassilopoulos, Athanasios Tsakris, Costas Tsioufis,
A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States,
Vaccine,
Volume 39, Issue 45,
2021,
Pages 6585-6590,
ISSN 0264-410X,
https://doi.org/10.1016/j.vaccine.2021.09.078.
(https://www.sciencedirect.com/science/article/pii/S0264410X21012950)
Abstract: Background
COVID-19 vaccines were efficacious and safe in clinical trials. We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273 (1/9).
Methods
All patients were referred for AP temporally linked with COVID-19 vaccination. Chest pain was the most common clinical manifestation. Alternative etiologies were excluded upon thorough diagnostic work up. AP diagnosis was established according to ESC guidelines.
Findings
Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without sequelae; two events were complicated by cardiac tamponade requiring emergent pericardial decompression. Hospitalization was required in four cases.
Interpretation
Although causality cannot be firmly established, AP has emerged as a possible complication following COVID-19 vaccination. Further investigation is indispensable to fully characterize this new entity.
Keywords: COVID-19 vaccination; Pericarditis; mRNA vaccines; Adenovirus vector-based vaccines; SARS-CoV-2, outcome