tetano
Editor, Senior Moderator
Blood Purif. 2013 Nov 1;36(2):112-115. [Epub ahead of print]
A Lethal Case of Influenza and Type 5 Cardiorenal Syndrome.
Larsen TR, Kinni V, Zaks J, David S, McCullough PA.
Source
Department of Internal Medicine, Section of Cardiology, Providence Hospitals and Medical Centers, Southfield, Mich., USA.
Abstract
Interactions between the heart and kidneys have been labeled as the cardiorenal syndrome (CRS). Type-5 CRS describes a disease that simultaneously damages both organs. With severe infection, systemic inflammatory mediators (TNF-α and IL-1β) cause wide-spread endothelial dysfunction, cellular apoptosis, and depressed organ function. Impaired myocardial function promotes worsening renal function and vice versa, leading to a dangerous positive feedback loop. Influenza viruses cause both myocardial and kidney injury, presumably through an immune-mediated mechanism. Herein we present a lethal case of influenza, resulting in acute type V cardiorenal syndrome. ? 2013 S. Karger AG, Basel.
PMID:
24192807
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24192807
A Lethal Case of Influenza and Type 5 Cardiorenal Syndrome.
Larsen TR, Kinni V, Zaks J, David S, McCullough PA.
Source
Department of Internal Medicine, Section of Cardiology, Providence Hospitals and Medical Centers, Southfield, Mich., USA.
Abstract
Interactions between the heart and kidneys have been labeled as the cardiorenal syndrome (CRS). Type-5 CRS describes a disease that simultaneously damages both organs. With severe infection, systemic inflammatory mediators (TNF-α and IL-1β) cause wide-spread endothelial dysfunction, cellular apoptosis, and depressed organ function. Impaired myocardial function promotes worsening renal function and vice versa, leading to a dangerous positive feedback loop. Influenza viruses cause both myocardial and kidney injury, presumably through an immune-mediated mechanism. Herein we present a lethal case of influenza, resulting in acute type V cardiorenal syndrome. ? 2013 S. Karger AG, Basel.
PMID:
24192807
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24192807