tetano
Editor, Senior Moderator
Angew Chem Int Ed Engl. 1998 Jun 19;37(11):1524-1528. doi: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D.
[h=1]A Lysoganglioside/Poly-L-glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin.[/h] Kamitakahara H[SUP]1[/SUP], Suzuki T[SUP]2[/SUP], Nishigori N[SUP]2[/SUP], Suzuki Y[SUP]2[/SUP], Kanie O[SUP]1[/SUP], Wong CH[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Based on the principle of a multivalent interaction, the amphiphilic polymer 1, present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemaglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 10[SUP]6[/SUP] -fold greater than that of sialyllactose. PGA=polyglutamic acid.
[h=4]KEYWORDS:[/h] Amphiphiles; Gangliosides; Molecular recognition; Receptors; Sialic acids
PMID: 29710929 DOI: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D
[h=1]A Lysoganglioside/Poly-L-glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin.[/h] Kamitakahara H[SUP]1[/SUP], Suzuki T[SUP]2[/SUP], Nishigori N[SUP]2[/SUP], Suzuki Y[SUP]2[/SUP], Kanie O[SUP]1[/SUP], Wong CH[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Based on the principle of a multivalent interaction, the amphiphilic polymer 1, present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemaglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 10[SUP]6[/SUP] -fold greater than that of sialyllactose. PGA=polyglutamic acid.
[h=4]KEYWORDS:[/h] Amphiphiles; Gangliosides; Molecular recognition; Receptors; Sialic acids
PMID: 29710929 DOI: 10.1002/(SICI)1521-3773(19980619)37:11<1524::AID-ANIE1524>3.0.CO;2-D