tetano
Editor, Senior Moderator
Antiviral Res. 2014 Jan 29. pii: S0166-3542(14)00027-8. doi: 10.1016/j.antiviral.2014.01.015. [Epub ahead of print]
A New Class of Synthetic Anti-Lipopolysaccharide Peptides Inhibits Influenza A Virus Replication by Blocking Cellular Attachment.
Hoffmann J1, Schneider C1, Heinbockel L2, Brandenburg K2, Reimer R1, Gabriel G3.
Author information
Abstract
Influenza A viruses are a continuous threat to human health as illustrated by the 2009 H1N1 pandemic. Since circulating influenza virus strains become increasingly resistant against currently available drugs, the development of novel antivirals is urgently needed. Here, we have evaluated a recently described new class of broad-spectrum antiviral peptides (Synthetic Anti-Lipopolysaccharide Peptides; SALPs) for their potential to inhibit influenza virus replication in vitro and in vivo. We found that particularly SALP PEP 19-2.5 shows high binding affinities for the influenza virus receptor molecule, N-Acetylneuraminic acid, leading to impaired viral attachment and cellular entry. As a result, replication of several influenza virus subtypes (H7N7, H3N2 and 2009 pandemic H1N1) was strongly reduced. Furthermore, mice co-treated with PEP 19-2.5 were protected against an otherwise 100% lethal H7N7 influenza virus infection. These findings show that SALPs exhibit antiviral activity against influenza viruses by blocking virus attachment and entry into host cells. Thus, SALPs present a new class of broad-spectrum antiviral peptides for further development for influenza virus therapy.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Cellular attachment inhibitor, Influenza virus, Mouse model, Synthetic anti-lipopolysaccharide peptides (SALPs)
PMID:
24486207
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24486207
A New Class of Synthetic Anti-Lipopolysaccharide Peptides Inhibits Influenza A Virus Replication by Blocking Cellular Attachment.
Hoffmann J1, Schneider C1, Heinbockel L2, Brandenburg K2, Reimer R1, Gabriel G3.
Author information
Abstract
Influenza A viruses are a continuous threat to human health as illustrated by the 2009 H1N1 pandemic. Since circulating influenza virus strains become increasingly resistant against currently available drugs, the development of novel antivirals is urgently needed. Here, we have evaluated a recently described new class of broad-spectrum antiviral peptides (Synthetic Anti-Lipopolysaccharide Peptides; SALPs) for their potential to inhibit influenza virus replication in vitro and in vivo. We found that particularly SALP PEP 19-2.5 shows high binding affinities for the influenza virus receptor molecule, N-Acetylneuraminic acid, leading to impaired viral attachment and cellular entry. As a result, replication of several influenza virus subtypes (H7N7, H3N2 and 2009 pandemic H1N1) was strongly reduced. Furthermore, mice co-treated with PEP 19-2.5 were protected against an otherwise 100% lethal H7N7 influenza virus infection. These findings show that SALPs exhibit antiviral activity against influenza viruses by blocking virus attachment and entry into host cells. Thus, SALPs present a new class of broad-spectrum antiviral peptides for further development for influenza virus therapy.
Copyright ? 2014. Published by Elsevier B.V.
KEYWORDS:
Cellular attachment inhibitor, Influenza virus, Mouse model, Synthetic anti-lipopolysaccharide peptides (SALPs)
PMID:
24486207
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24486207