tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2013 Mar 6. [Epub ahead of print]
A Prospective Study of Agents Associated with Acute Respiratory Infection among Young American Indian Children.
Bhat N, Tokarz R, Jain K, Haq S, Weatherholtz R, Chandran A, Karron R, Reid R, Santosham M, O'Brien KL, Lipkin WI.
Source
1. Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2. Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA 3. Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Abstract
BACKGROUND:: Native American children have higher rates of morbidity associated with acute respiratory infection than children in the general United States population, yet detailed information is lacking regarding their principal clinical presentations and infectious etiologies. METHODS:: We pursued a comprehensive molecular survey of bacteria and viruses in nasal wash specimens from children with acute respiratory disease collected prospectively over one year (January 1 through December 31, 2009) from 915 Navajo and White Mountain Apache children in their second or third year of life who had been enrolled in an efficacy study of an RSV monoclonal antibody in the first year of life. RESULTS:: During the surveillance period, 1476 episodes of disease were detected in 669 children. Rates of outpatient and inpatient lower respiratory tract illness were 391 and 79 per 1000 child-years, respectively, and were most commonly diagnosed as pneumonia. Potential pathogens were detected in 88% of specimens. Viruses most commonly detected were respiratory syncytial virus (RSV) and human rhinovirus (HRV); 2009 pandemic influenza A (H1N1) illnesses primarily occurred in the fall. Streptococcus pneumoniae was detected in 60% of subjects; only HRV was significantly associated with S. pneumoniae carriage. The presence of influenza virus, HRV, or S. pneumoniae was not associated with increased risk for lower respiratory tract involvement or hospitalization. CONCLUSIONS:: Acute lower respiratory illnesses occur at disproportionately high rates among young American Indian children, and are associated with a range of common pathogens. This study provides critical evidence to support reducing the disproportionate burden of acute respiratory disease among young Native Americans.
PMID:
23470677
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23470677
A Prospective Study of Agents Associated with Acute Respiratory Infection among Young American Indian Children.
Bhat N, Tokarz R, Jain K, Haq S, Weatherholtz R, Chandran A, Karron R, Reid R, Santosham M, O'Brien KL, Lipkin WI.
Source
1. Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA 2. Center for Infection and Immunity, Columbia University Mailman School of Public Health, New York, NY, USA 3. Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Abstract
BACKGROUND:: Native American children have higher rates of morbidity associated with acute respiratory infection than children in the general United States population, yet detailed information is lacking regarding their principal clinical presentations and infectious etiologies. METHODS:: We pursued a comprehensive molecular survey of bacteria and viruses in nasal wash specimens from children with acute respiratory disease collected prospectively over one year (January 1 through December 31, 2009) from 915 Navajo and White Mountain Apache children in their second or third year of life who had been enrolled in an efficacy study of an RSV monoclonal antibody in the first year of life. RESULTS:: During the surveillance period, 1476 episodes of disease were detected in 669 children. Rates of outpatient and inpatient lower respiratory tract illness were 391 and 79 per 1000 child-years, respectively, and were most commonly diagnosed as pneumonia. Potential pathogens were detected in 88% of specimens. Viruses most commonly detected were respiratory syncytial virus (RSV) and human rhinovirus (HRV); 2009 pandemic influenza A (H1N1) illnesses primarily occurred in the fall. Streptococcus pneumoniae was detected in 60% of subjects; only HRV was significantly associated with S. pneumoniae carriage. The presence of influenza virus, HRV, or S. pneumoniae was not associated with increased risk for lower respiratory tract involvement or hospitalization. CONCLUSIONS:: Acute lower respiratory illnesses occur at disproportionately high rates among young American Indian children, and are associated with a range of common pathogens. This study provides critical evidence to support reducing the disproportionate burden of acute respiratory disease among young Native Americans.
PMID:
23470677
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23470677