tetano
Editor, Senior Moderator
Org Lett. 2012 Nov 26. [Epub ahead of print]
A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors.
Brant MG, Wulff JE.
Source
Department of Chemistry, University of Victoria , Victoria, BC, Canada, V8W 3V6.
Abstract
Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.
PMID:
23181823
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23181823
A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors.
Brant MG, Wulff JE.
Source
Department of Chemistry, University of Victoria , Victoria, BC, Canada, V8W 3V6.
Abstract
Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.
PMID:
23181823
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23181823