tetano
Editor, Senior Moderator
BMC Med Res Methodol. 2017 Feb 21;17(1):31. doi: 10.1186/s12874-017-0300-1.
[h=1]A statistical method utilizing information of imported cases to estimate the transmissibility for an influenza pandemic.[/h] Chong KC[SUP]1,[/SUP][SUP]2[/SUP], Zee BC[SUP]1,[/SUP][SUP]2[/SUP], Wang MH[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connecting the originating country with other regions. It can be a complete and timely source for estimating the basic reproduction number (R [SUB]0[/SUB] ), a key indicator of disease transmissibility.
[h=4]METHOD:[/h] In this study, we developed a likelihood-based method using arrival times of infected cases in different countries to estimate R [SUB]0[/SUB] for influenza pandemics. A simulation was conducted to assess the performance of the proposed method. We further applied the method to the outbreak of the influenza pandemic A/H1N1 in Mexico.
[h=4]RESULTS:[/h] In the numerical application, the estimated R [SUB]0[/SUB] was equal to 1.69 with a 95% confidence interval (1.65, 1.73). For the simulation results, the estimations were robust to the decline of travel rate and other parameter assumptions. Nevertheless, the estimates were moderately sensitive to the assumption of infectious duration. Generally, the findings were in line with other relevant studies.
[h=4]CONCLUSIONS:[/h] Our approach as well as the estimate is potential to assist officials in planning control and prevention measures. Improved coordination to streamline or even centralize surveillance of imported cases among countries will thus be beneficial to public health.
[h=4]KEYWORDS:[/h] Basic reproduction number; Epidemic models; Influenza pandemic; SIR model; Travel data
PMID: 28222682 DOI: 10.1186/s12874-017-0300-1
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[h=1]A statistical method utilizing information of imported cases to estimate the transmissibility for an influenza pandemic.[/h] Chong KC[SUP]1,[/SUP][SUP]2[/SUP], Zee BC[SUP]1,[/SUP][SUP]2[/SUP], Wang MH[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] In a new influenza pandemic, travel data such as arrival times of cases seeded by the originating country can be regarded as a combination of the epidemic size and the mobility networks of infections connecting the originating country with other regions. It can be a complete and timely source for estimating the basic reproduction number (R [SUB]0[/SUB] ), a key indicator of disease transmissibility.
[h=4]METHOD:[/h] In this study, we developed a likelihood-based method using arrival times of infected cases in different countries to estimate R [SUB]0[/SUB] for influenza pandemics. A simulation was conducted to assess the performance of the proposed method. We further applied the method to the outbreak of the influenza pandemic A/H1N1 in Mexico.
[h=4]RESULTS:[/h] In the numerical application, the estimated R [SUB]0[/SUB] was equal to 1.69 with a 95% confidence interval (1.65, 1.73). For the simulation results, the estimations were robust to the decline of travel rate and other parameter assumptions. Nevertheless, the estimates were moderately sensitive to the assumption of infectious duration. Generally, the findings were in line with other relevant studies.
[h=4]CONCLUSIONS:[/h] Our approach as well as the estimate is potential to assist officials in planning control and prevention measures. Improved coordination to streamline or even centralize surveillance of imported cases among countries will thus be beneficial to public health.
[h=4]KEYWORDS:[/h] Basic reproduction number; Epidemic models; Influenza pandemic; SIR model; Travel data
PMID: 28222682 DOI: 10.1186/s12874-017-0300-1
[PubMed - in process] Free full text