tetano
Editor, Senior Moderator
Access Microbiol
. 2023 May 26;5(5):acmi000547.v4.
doi: 10.1099/acmi.0.000547.v4. eCollection 2023. Viral infectivity in paediatric SARS-CoV-2 clinical samples does not vary by age
Madaline M Schmidt[SUP] 1 [/SUP], Hannah W Despres[SUP] 1 [/SUP], David J Shirley[SUP] 2 [/SUP], Michael E Bose[SUP] 3 [/SUP], Kate C McCaul[SUP] 3 [/SUP], Jessica W Crothers[SUP] 4 [/SUP], Kelly J Henrickson[SUP] 3 [/SUP], Benjamin Lee[SUP] 5 [/SUP], Emily A Bruce[SUP] 1 [/SUP]
Affiliations
At the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there was much uncertainty about the role of children in infection and transmission dynamics. Through the course of the pandemic, it became clear that children were susceptible to SARS-CoV-2 infection, although they were experiencing a notable lack of severe disease outcomes as compared to the adult population. This trend held true with the emergence of new SARS-CoV-2 variants, even in paediatric populations that were ineligible to be vaccinated. The difference in disease outcomes has prompted questions about the virological features of SARS-CoV-2 infection in this population. In order to determine if there was any difference in the infectivity of the virus produced by children with coronavirus disease 2019 (COVID-19), we compared viral RNA levels (clinical RT-qPCR C [SUB]T[/SUB]) and infectious virus titres from 144 SARS-CoV-2-positive clinical samples collected from children aged 0 to 18 years old. We found that age had no impact on the infectiousness of SARS-CoV-2 within our cohort, with children of all ages able to produce high levels of infectious virus.
Keywords: SARS-CoV-2; clinical isolates; paediatric; viral infectivity.
. 2023 May 26;5(5):acmi000547.v4.
doi: 10.1099/acmi.0.000547.v4. eCollection 2023. Viral infectivity in paediatric SARS-CoV-2 clinical samples does not vary by age
Madaline M Schmidt[SUP] 1 [/SUP], Hannah W Despres[SUP] 1 [/SUP], David J Shirley[SUP] 2 [/SUP], Michael E Bose[SUP] 3 [/SUP], Kate C McCaul[SUP] 3 [/SUP], Jessica W Crothers[SUP] 4 [/SUP], Kelly J Henrickson[SUP] 3 [/SUP], Benjamin Lee[SUP] 5 [/SUP], Emily A Bruce[SUP] 1 [/SUP]
Affiliations
- PMID: 37323941
- PMCID: PMC10267661
- DOI: 10.1099/acmi.0.000547.v4
At the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there was much uncertainty about the role of children in infection and transmission dynamics. Through the course of the pandemic, it became clear that children were susceptible to SARS-CoV-2 infection, although they were experiencing a notable lack of severe disease outcomes as compared to the adult population. This trend held true with the emergence of new SARS-CoV-2 variants, even in paediatric populations that were ineligible to be vaccinated. The difference in disease outcomes has prompted questions about the virological features of SARS-CoV-2 infection in this population. In order to determine if there was any difference in the infectivity of the virus produced by children with coronavirus disease 2019 (COVID-19), we compared viral RNA levels (clinical RT-qPCR C [SUB]T[/SUB]) and infectious virus titres from 144 SARS-CoV-2-positive clinical samples collected from children aged 0 to 18 years old. We found that age had no impact on the infectiousness of SARS-CoV-2 within our cohort, with children of all ages able to produce high levels of infectious virus.
Keywords: SARS-CoV-2; clinical isolates; paediatric; viral infectivity.