tetano
Editor, Senior Moderator
ACS Chem Neurosci
. 2021 Jun 8.
doi: 10.1021/acschemneuro.1c00111. Online ahead of print.
Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
Mahdi Eskandarian Boroujeni[SUP] 1 [/SUP], Leila Simani[SUP] 2 [/SUP], Hans A R Bluyssen[SUP] 1 [/SUP], Hamid Reza Samadikhah[SUP] 3 [/SUP], Soheila Zamanlui Benisi[SUP] 4 [/SUP], Sanaz Hassani[SUP] 1 [/SUP], Nader Akbari Dilmaghani[SUP] 2 [/SUP], Mobina Fathi[SUP] 5 [/SUP], Kimia Vakili[SUP] 5 [/SUP], Gholam-Reza Mahmoudiasl[SUP] 6 7 [/SUP], Hojjat Allah Abbaszadeh[SUP] 7 8 [/SUP], Meysam Hassani Moghaddam[SUP] 9 [/SUP], Mohammad-Amin Abdollahifar[SUP] 8 10 [/SUP], Abbas Aliaghaei[SUP] 8 10 [/SUP]
Affiliations
Abstract
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17, 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes IL1B, IL6, IFITM, MX1, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a glial-mediated neuroinflammation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.
Keywords: COVID-19; cerebral cortex; neuroinflammation; oxidative stress.
. 2021 Jun 8.
doi: 10.1021/acschemneuro.1c00111. Online ahead of print.
Inflammatory Response Leads to Neuronal Death in Human Post-Mortem Cerebral Cortex in Patients with COVID-19
Mahdi Eskandarian Boroujeni[SUP] 1 [/SUP], Leila Simani[SUP] 2 [/SUP], Hans A R Bluyssen[SUP] 1 [/SUP], Hamid Reza Samadikhah[SUP] 3 [/SUP], Soheila Zamanlui Benisi[SUP] 4 [/SUP], Sanaz Hassani[SUP] 1 [/SUP], Nader Akbari Dilmaghani[SUP] 2 [/SUP], Mobina Fathi[SUP] 5 [/SUP], Kimia Vakili[SUP] 5 [/SUP], Gholam-Reza Mahmoudiasl[SUP] 6 7 [/SUP], Hojjat Allah Abbaszadeh[SUP] 7 8 [/SUP], Meysam Hassani Moghaddam[SUP] 9 [/SUP], Mohammad-Amin Abdollahifar[SUP] 8 10 [/SUP], Abbas Aliaghaei[SUP] 8 10 [/SUP]
Affiliations
- PMID: 34100287
- DOI: 10.1021/acschemneuro.1c00111
Abstract
The recent coronavirus disease of 2019 (COVID-19) pandemic has adversely affected people worldwide. A growing body of literature suggests the neurological complications and manifestations in response to COVID-19 infection. Herein, we explored the inflammatory and immune responses in the post-mortem cerebral cortex of patients with severe COVID-19. The participants comprised three patients diagnosed with severe COVID-19 from March 26, 2020, to April 17, 2020, and three control patients. Our findings demonstrated a surge in the number of reactive astrocytes and activated microglia, as well as low levels of glutathione along with the upregulation of inflammation- and immune-related genes IL1B, IL6, IFITM, MX1, and OAS2 in the COVID-19 group. Overall, the data imply that oxidative stress may invoke a glial-mediated neuroinflammation, which ultimately leads to neuronal cell death in the cerebral cortex of COVID-19 patients.
Keywords: COVID-19; cerebral cortex; neuroinflammation; oxidative stress.