tetano
Editor, Senior Moderator
Acta Neurol Belg
. 2020 Jul 21.
doi: 10.1007/s13760-020-01421-3. Online ahead of print.
Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain-Barr? syndrome
Giuliana Galassi[SUP] 1 [/SUP], Alessandro Marchioni[SUP] 2 [/SUP]
Affiliations
Abstract
In December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia from Wuhan, China, aroused worldwide concern due to an escalating outbreak in all the countries in the world. Coronavirus belongs to a family of single-stranded RNA viruses, which includes severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV), that have caused human epidemics with high fatality. The spectrum of the novel coronavirus disease (SARS-Co-2 or COVID-19) ranges from asymptomatic infections to fatal pneumonia, and differs from other viral pulmonary infections. MERS-CoV is known to be potentially neuroinvasive. Extensive reports from China documented central and peripheral nervous system involvement in patients with COVID-19, and identified in angiotensin converting enzyme2 (ACE2), which is present in multiple human organs, the functional receptor for this virus. Guillain-Barr? syndrome (GBS) has recently been associated to COVID-19 rising concern among physicians. This review summarizes the current state of knowledge on GBS during or after COVID-19 infection, attempting to clarify the pathophysiology of the associated respiratory dysfunction and failure.
Keywords: Acute axonal; Acute respiratory distress (ARDS); COVID-19; Demyelinating neuropathy; Guillain–Barr? syndrome; MERS-CoV; SARS-CoV.
. 2020 Jul 21.
doi: 10.1007/s13760-020-01421-3. Online ahead of print.
Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain-Barr? syndrome
Giuliana Galassi[SUP] 1 [/SUP], Alessandro Marchioni[SUP] 2 [/SUP]
Affiliations
- PMID: 32696312
- DOI: 10.1007/s13760-020-01421-3
Abstract
In December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia from Wuhan, China, aroused worldwide concern due to an escalating outbreak in all the countries in the world. Coronavirus belongs to a family of single-stranded RNA viruses, which includes severe acute respiratory syndrome (SARS-CoV) and Middle East respiratory syndrome (MERS-CoV), that have caused human epidemics with high fatality. The spectrum of the novel coronavirus disease (SARS-Co-2 or COVID-19) ranges from asymptomatic infections to fatal pneumonia, and differs from other viral pulmonary infections. MERS-CoV is known to be potentially neuroinvasive. Extensive reports from China documented central and peripheral nervous system involvement in patients with COVID-19, and identified in angiotensin converting enzyme2 (ACE2), which is present in multiple human organs, the functional receptor for this virus. Guillain-Barr? syndrome (GBS) has recently been associated to COVID-19 rising concern among physicians. This review summarizes the current state of knowledge on GBS during or after COVID-19 infection, attempting to clarify the pathophysiology of the associated respiratory dysfunction and failure.
Keywords: Acute axonal; Acute respiratory distress (ARDS); COVID-19; Demyelinating neuropathy; Guillain–Barr? syndrome; MERS-CoV; SARS-CoV.